1soa: Difference between revisions

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[[Image:1soa.gif|left|200px]]
{{Seed}}
[[Image:1soa.png|left|200px]]


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{{STRUCTURE_1soa|  PDB=1soa  |  SCENE=  }}  
{{STRUCTURE_1soa|  PDB=1soa  |  SCENE=  }}  


'''Human DJ-1 with sulfinic acid'''
===Human DJ-1 with sulfinic acid===




==Overview==
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Loss-of-function DJ-1 mutations can cause early-onset Parkinson's disease. The function of DJ-1 is unknown, but an acidic isoform accumulates after oxidative stress, leading to the suggestion that DJ-1 is protective under these conditions. We addressed whether this represents a posttranslational modification at cysteine residues by systematically mutating cysteine residues in human DJ-1. WT or C53A DJ-1 was readily oxidized in cultured cells, generating a pI 5.8 isoform, but an artificial C106A mutant was not. We observed a cysteine-sulfinic acid at C106 in crystalline DJ-1 but no modification of C53 or C46. Oxidation of DJ-1 was promoted by the crystallization procedure. In addition, oxidation-induced mitochondrial relocalization of DJ-1 and protection against cell death were abrogated in C106A but not C53A or C46A. We suggest that DJ-1 protects against neuronal death, and that this is signaled by acidification of the key cysteine residue, C106.
The line below this paragraph, {{ABSTRACT_PUBMED_15181200}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15181200 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15181200}}


==About this Structure==
==About this Structure==
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[[Category: Dj-1/thij/pfpi familiy]]
[[Category: Dj-1/thij/pfpi familiy]]
[[Category: Parkinson's disease]]
[[Category: Parkinson's disease]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:56:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:46:33 2008''

Revision as of 19:46, 27 July 2008

File:1soa.png

Template:STRUCTURE 1soa

Human DJ-1 with sulfinic acid

Template:ABSTRACT PUBMED 15181200

About this Structure

1SOA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization., Canet-Aviles RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, Cookson MR, Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9103-8. Epub 2004 Jun 4. PMID:15181200

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