1jwt: Difference between revisions

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[[Image:1jwt.jpg|left|200px]]
{{Seed}}
[[Image:1jwt.png|left|200px]]


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{{STRUCTURE_1jwt|  PDB=1jwt  |  SCENE=  }}  
{{STRUCTURE_1jwt|  PDB=1jwt  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR'''
===CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR===




==Overview==
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Peptidomimetic inhibitors of thrombin lacking the important Ser195-carbonyl interaction have been prepared. The binding energy lost after the removal of the activated carbonyl was recaptured through a series of modifications of the P1 residues of the bicyclic lactam inhibitors. Selected substituted compounds displayed useful pharmacological profiles both in vitro and in vivo.
The line below this paragraph, {{ABSTRACT_PUBMED_11720865}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11720865 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11720865}}


==About this Structure==
==About this Structure==
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[[Category: Winocour, P D.]]
[[Category: Winocour, P D.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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