2tbd: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:2tbd.jpg|left|200px]]
{{Seed}}
[[Image:2tbd.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2tbd|  PDB=2tbd  |  SCENE=  }}  
{{STRUCTURE_2tbd|  PDB=2tbd  |  SCENE=  }}  


'''SV40 T ANTIGEN DNA-BINDING DOMAIN, NMR, 30 STRUCTURES'''
===SV40 T ANTIGEN DNA-BINDING DOMAIN, NMR, 30 STRUCTURES===




==Overview==
<!--
The structure of the domain from simian virus 40 (SV40) large T-antigen that binds to the SV40 origin of DNA replication (T-ag-OBD131-260) has been determined by nuclear magnetic resonance spectroscopy. The overall fold, consisting of a central five-stranded antiparallel beta-sheet flanked by two alpha-helices on one side and one alpha-helix and one 3(10)-helix on the other, is a new one. Previous mutational analyses have identified two elements, termed A (approximately 152-155) and B2 (203-207), as essential for origin-specific recognition. These elements form two closely juxtaposed loops that define a continuous surface on the protein. The addition of a duplex oligonucleotide containing the origin recognition pentanucleotide GAGGC induces chemical shift changes and slows amide proton exchange in resonances from this region, indicating that this surface directly contacts the DNA.
The line below this paragraph, {{ABSTRACT_PUBMED_8946857}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8946857 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_8946857}}


==About this Structure==
==About this Structure==
2TBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_virus_40 Simian virus 40]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TBD OCA].  
2TBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_virus_40 Simian virus 40]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TBD OCA].  


==Reference==
==Reference==
Line 32: Line 36:
[[Category: Origin-binding domain]]
[[Category: Origin-binding domain]]
[[Category: Replication]]
[[Category: Replication]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:22:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:16:07 2008''
Retrieved from "https://proteopedia.org/2tbd"