1u02: Difference between revisions

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[[Image:1u02.gif|left|200px]]
{{Seed}}
[[Image:1u02.png|left|200px]]


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{{STRUCTURE_1u02|  PDB=1u02  |  SCENE=  }}  
{{STRUCTURE_1u02|  PDB=1u02  |  SCENE=  }}  


'''Crystal structure of trehalose-6-phosphate phosphatase related protein'''
===Crystal structure of trehalose-6-phosphate phosphatase related protein===




==Overview==
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We report here the crystal structure of a trehalose-6-phosphate phosphatase-related protein (T6PP) from Thermoplasma acidophilum, TA1209, determined by the dual-wavelength anomalous diffraction (DAD) method. T6PP is a member of the haloacid dehalogenase (HAD) superfamily with significant sequence homology with trehalose-6-phosphate phosphatase, phosphoserine phosphatase, P-type ATPases and other members of the family. T6PP possesses a core domain of known alpha/beta-hydrolase fold, characteristic of the HAD family, and a cap domain, with a tertiary fold consisting of a four-stranded beta-sheet with two alpha-helices on one side of the sheet. An active-site magnesium ion and a glycerol molecule bound at the interface between the two domains provide insight into the mode of substrate binding by T6PP. A trehalose-6-phosphate molecule modeled into a cage formed by the two domains makes favorable interactions with the protein molecule. We have confirmed that T6PP is a trehalose phosphatase from amino acid sequence, three-dimensional structure, and biochemical assays.
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{{ABSTRACT_PUBMED_16815921}}


==About this Structure==
==About this Structure==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:34:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:25:44 2008''

Revision as of 20:25, 27 July 2008

File:1u02.png

Template:STRUCTURE 1u02

Crystal structure of trehalose-6-phosphate phosphatase related protein

Template:ABSTRACT PUBMED 16815921

About this Structure

1U02 is a Single protein structure of sequence from Thermoplasma acidophilum. Full crystallographic information is available from OCA.

Reference

Crystal structure of trehalose-6-phosphate phosphatase-related protein: biochemical and biological implications., Rao KN, Kumaran D, Seetharaman J, Bonanno JB, Burley SK, Swaminathan S, Protein Sci. 2006 Jul;15(7):1735-44. PMID:16815921

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