2z3q: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:2z3q.gif|left|200px]]
{{Seed}}
[[Image:2z3q.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2z3q|  PDB=2z3q  |  SCENE=  }}  
{{STRUCTURE_2z3q|  PDB=2z3q  |  SCENE=  }}  


'''Crystal structure of the IL-15/IL-15Ra complex'''
===Crystal structure of the IL-15/IL-15Ra complex===




==Overview==
<!--  
Interleukin 15 (IL-15) and IL-2, which promote the survival of memory CD8(+) T cells and regulatory T cells, respectively, bind receptor complexes that share beta- and gamma-signaling subunits. Receptor specificity is provided by unique, nonsignaling alpha-subunits. Whereas IL-2 receptor-alpha (IL-2Ralpha) is expressed together in cis with the beta- and gamma-subunits on T cells and B cells, IL-15Ralpha is expressed in trans on antigen-presenting cells. Here we present a 1.85-A crystal structure of the human IL-15-IL-15Ralpha complex. The structure provides insight into the molecular basis of the specificity of cytokine recognition and emphasizes the importance of water in generating this very high-affinity complex. Despite very low IL-15-IL-2 sequence homology and distinct receptor architecture, the topologies of the IL-15-IL-15Ralpha and IL-2-IL-2Ralpha complexes are very similar. Our data raise the possibility that IL-2, like IL-15, might be capable of being presented in trans in the context of its unique receptor alpha-chain.
The line below this paragraph, {{ABSTRACT_PUBMED_17643103}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17643103 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17643103}}


==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Cytokine/cytokine receptor complex]]
[[Category: Cytokine/cytokine receptor complex]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 19:55:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:35:41 2008''
Retrieved from "https://proteopedia.org/2z3q"