296d: Difference between revisions

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[[Image:296d.gif|left|200px]]
{{Seed}}
[[Image:296d.png|left|200px]]


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{{STRUCTURE_296d|  PDB=296d  |  SCENE=  }}  
{{STRUCTURE_296d|  PDB=296d  |  SCENE=  }}  


'''SEQUENCE-DEPENDENT EFFECTS IN DRUG-DNA INTERACTION: THE CRYSTAL STRUCTURE OF HOECHST 33258 BOUND TO THE D(CGCAAATTTGCG)2 DUPLEX'''
===SEQUENCE-DEPENDENT EFFECTS IN DRUG-DNA INTERACTION: THE CRYSTAL STRUCTURE OF HOECHST 33258 BOUND TO THE D(CGCAAATTTGCG)2 DUPLEX===




==Overview==
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The bis-benzimidazole drug Hoechst 33258 has been co-crystallized with the dodecanucleotide sequence d(CGCAAATTTGCG)2. The structure has been solved by molecular replacement and refined to an R factor of 18.5% for 2125 reflections collected on a Xentronics area detector. The drug is bound in the minor groove, at the five base-pair site 5'-ATTTG and is in a unique orientation. This is displaced by one base pair in the 5' direction compared to previously-determined structures of this drug with the sequence d(CGCGAATTCGCG)2. Reasons for this difference in behaviour are discussed in terms of several sequence-dependent structural features of the DNA, with particular reference to differences in propeller twist and minor-groove width.
The line below this paragraph, {{ABSTRACT_PUBMED_7515488}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 7515488 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7515488}}


==About this Structure==
==About this Structure==
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[[Category: Complexed with drug]]
[[Category: Complexed with drug]]
[[Category: Double helix]]
[[Category: Double helix]]
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