2ixz: Difference between revisions

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[[Image:2ixz.gif|left|200px]]
{{Seed}}
[[Image:2ixz.png|left|200px]]


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{{STRUCTURE_2ixz|  PDB=2ixz  |  SCENE=  }}  
{{STRUCTURE_2ixz|  PDB=2ixz  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE APICAL STEM-LOOP OF THE HUMAN HEPATITIS B VIRUS ENCAPSIDATION SIGNAL'''
===SOLUTION STRUCTURE OF THE APICAL STEM-LOOP OF THE HUMAN HEPATITIS B VIRUS ENCAPSIDATION SIGNAL===




==Overview==
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Hepatitis B virus (HBV) replication is initiated by HBV RT binding to the highly conserved encapsidation signal, epsilon, at the 5' end of the RNA pregenome. Epsilon contains an apical stem-loop, whose residues are either totally conserved or show rare non-disruptive mutations. Here we present the structure of the apical stem-loop based on NOE, RDC and (1)H chemical shift NMR data. The (1)H chemical shifts proved to be crucial to define the loop conformation. The loop sequence 5'-CUGUGC-3' folds into a UGU triloop with a CG closing base pair and a bulged out C and hence forms a pseudo-triloop, a proposed protein recognition motif. In the UGU loop conformations most consistent with experimental data, the guanine nucleobase is located on the minor groove face and the two uracil bases on the major groove face. The underlying helix is disrupted by a conserved non-paired U bulge. This U bulge adopts multiple conformations, with the nucleobase being located either in the major groove or partially intercalated in the helix from the minor groove side, and bends the helical stem. The pseudo-triloop motif, together with the U bulge, may represent important anchor points for the initial recognition of epsilon by the viral RT.
The line below this paragraph, {{ABSTRACT_PUBMED_16945960}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16945960 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16945960}}


==About this Structure==
==About this Structure==
2IXZ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXZ OCA].  
2IXZ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXZ OCA].  


==Reference==
==Reference==
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[[Category: Rdc]]
[[Category: Rdc]]
[[Category: Rna]]
[[Category: Rna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:03:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:49:29 2008''

Revision as of 20:49, 27 July 2008

File:2ixz.png

Template:STRUCTURE 2ixz

SOLUTION STRUCTURE OF THE APICAL STEM-LOOP OF THE HUMAN HEPATITIS B VIRUS ENCAPSIDATION SIGNAL

Template:ABSTRACT PUBMED 16945960

About this Structure

2IXZ is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of the apical stem-loop of the human hepatitis B virus encapsidation signal., Flodell S, Petersen M, Girard F, Zdunek J, Kidd-Ljunggren K, Schleucher J, Wijmenga S, Nucleic Acids Res. 2006;34(16):4449-57. Epub 2006 Aug 31. PMID:16945960

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