229d: Difference between revisions

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[[Image:229d.gif|left|200px]]
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[[Image:229d.png|left|200px]]


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{{STRUCTURE_229d|  PDB=229d  |  SCENE=  }}  
{{STRUCTURE_229d|  PDB=229d  |  SCENE=  }}  


'''DNA ANALOG OF YEAST TRANSFER RNA PHE ANTICODON DOMAIN WITH MODIFIED BASES 5-METHYL CYTOSINE AND 1-METHYL GUANINE'''
===DNA ANALOG OF YEAST TRANSFER RNA PHE ANTICODON DOMAIN WITH MODIFIED BASES 5-METHYL CYTOSINE AND 1-METHYL GUANINE===




==Overview==
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Design of biologically active DNA analogues of the yeast tRNA(Phe) anticodon domain, tDNAPheAC, required the introduction of a d(m5C)-dependent, Mg(2+)-induced structural transition and the d(m1G) disruption of an intra-loop dC.dG base pair. The modifications were introduced at residues corresponding to m5C-40 and wybutosine-37 in tRNA(Phe). Modified tDNAPheAC inhibited translation by 50% at a tDNAPheAC:ribosome ratio of 8:1. The molecule's structure has been determined by NMR spectroscopy and restrained molecular dynamics with an overall r.m.s.d. of 2.8 A and 1.7 A in the stem, and is similar to the tRNA(Phe) anticodon domain in conformation and dimensions. The tDNAPheAC structure may provide a guide for the design of translation inhibitors as potential therapeutic agents.
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{{ABSTRACT_PUBMED_8548453}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=229D OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=229D OCA].  


==Reference==
==Reference==
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[[Category: Hairpin loop]]
[[Category: Hairpin loop]]
[[Category: Transfer rna]]
[[Category: Transfer rna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:20:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:58:26 2008''

Revision as of 20:58, 27 July 2008

File:229d.png

Template:STRUCTURE 229d

DNA ANALOG OF YEAST TRANSFER RNA PHE ANTICODON DOMAIN WITH MODIFIED BASES 5-METHYL CYTOSINE AND 1-METHYL GUANINE

Template:ABSTRACT PUBMED 8548453

About this Structure

Full experimental information is available from OCA.

Reference

Design, biological activity and NMR-solution structure of a DNA analogue of yeast tRNA(Phe) anticodon domain., Basti MM, Stuart JW, Lam AT, Guenther R, Agris PF, Nat Struct Biol. 1996 Jan;3(1):38-44. PMID:8548453

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