3b95: Difference between revisions

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[[Image:3b95.~~jpg~~|left|200px]]

[[Image:3b95.png|left|200px]]

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~~'''~~EuHMT1 (Glp) Ankyrin Repeat Domain (Structure 2)~~'''~~

===EuHMT1 (Glp) Ankyrin Repeat Domain (Structure 2)===

~~==Overview==~~

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~~Histone modifications have important roles in transcriptional control~~, mitosis and heterochromatin formation. G9a and G9a-like protein (GLP) are euchromatin-associated methyltransferases that repress transcription by mono- and dimethylating histone H3 at Lys9 (H3K9). Here we demonstrate that the ~~ankyrin repeat domains of G9a and GLP bind with strong preference~~ to ~~N-terminal H3 peptides containing mono- or dimethyl K9. X-ray crystallography revealed~~ the ~~basis for recognition of the methylated lysine by a partial hydrophobic cage with three tryptophans and one acidic residue~~. ~~Substitution of key residues in the cage eliminated the H3 tail interaction~~. ~~Hence~~, ~~G9a and GLP contain a new type of methyllysine binding module (the ankyrin repeat domains) and are~~ the ~~first examples of protein (histone) methyltransferases harboring in a single polypeptide the activities that generate and read the same epigenetic mark~~.

The line below this paragraph, {{ABSTRACT_PUBMED_18264113}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18264113 is the PubMed ID number.

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==Disease==

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[[Category: Transferase]]

[[Category: Transferase/structual protein complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 20~~:32:20 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:03:22 2008''

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-[[Image:3b95.jpg|left|200px]]
+{{Seed}}
+[[Image:3b95.png|left|200px]]
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 {{STRUCTURE_3b95|  PDB=3b95  |  SCENE=  }}
-'''EuHMT1 (Glp) Ankyrin Repeat Domain (Structure 2)'''
+===EuHMT1 (Glp) Ankyrin Repeat Domain (Structure 2)===
-==Overview==
+<!--
-Histone modifications have important roles in transcriptional control, mitosis and heterochromatin formation. G9a and G9a-like protein (GLP) are euchromatin-associated methyltransferases that repress transcription by mono- and dimethylating histone H3 at Lys9 (H3K9). Here we demonstrate that the ankyrin repeat domains of G9a and GLP bind with strong preference to N-terminal H3 peptides containing mono- or dimethyl K9. X-ray crystallography revealed the basis for recognition of the methylated lysine by a partial hydrophobic cage with three tryptophans and one acidic residue. Substitution of key residues in the cage eliminated the H3 tail interaction. Hence, G9a and GLP contain a new type of methyllysine binding module (the ankyrin repeat domains) and are the first examples of protein (histone) methyltransferases harboring in a single polypeptide the activities that generate and read the same epigenetic mark.
+The line below this paragraph, {{ABSTRACT_PUBMED_18264113}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18264113 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18264113}}
 ==Disease==
@@ Line 33: / Line 37: @@
 [[Category: Transferase]]
 [[Category: Transferase/structual protein complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:32:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:03:22 2008''