1pd2: Difference between revisions

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[[Image:1pd2.gif|left|200px]]
{{Seed}}
[[Image:1pd2.png|left|200px]]


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{{STRUCTURE_1pd2|  PDB=1pd2  |  SCENE=  }}  
{{STRUCTURE_1pd2|  PDB=1pd2  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE COMPLEX WITH GLUTATHIONE'''
===CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE COMPLEX WITH GLUTATHIONE===




==Overview==
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Hematopoietic prostaglandin (PG) D synthase is the key enzyme for production of the D and J series of prostanoids in the immune system and mast cells. We isolated a cDNA for the rat enzyme, crystallized the recombinant enzyme, and determined the three-dimensional structure of the enzyme complexed with glutathione at 2.3 A resolution. The enzyme is the first member of the sigma class glutathione S-transferase (GST) from vertebrates and possesses a prominent cleft as the active site, which is never seen among other members of the GST family. The unique 3-D architecture of the cleft leads to the putative substrate binding mode and its catalytic mechanism, responsible for the specific isomerization from PGH2 to PGD2.
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{{ABSTRACT_PUBMED_9323136}}


==About this Structure==
==About this Structure==
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[[Category: Pgd]]
[[Category: Pgd]]
[[Category: Sigma-class gst]]
[[Category: Sigma-class gst]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:57:14 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:19:32 2008''

Revision as of 21:19, 27 July 2008

File:1pd2.png

Template:STRUCTURE 1pd2

CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE COMPLEX WITH GLUTATHIONE

Template:ABSTRACT PUBMED 9323136

About this Structure

1PD2 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Cloning and crystal structure of hematopoietic prostaglandin D synthase., Kanaoka Y, Ago H, Inagaki E, Nanayama T, Miyano M, Kikuno R, Fujii Y, Eguchi N, Toh H, Urade Y, Hayaishi O, Cell. 1997 Sep 19;90(6):1085-95. PMID:9323136

Page seeded by OCA on Mon Jul 28 00:19:32 2008

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