1wu3: Difference between revisions

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[[Image:1wu3.jpg|left|200px]]
{{Seed}}
[[Image:1wu3.png|left|200px]]


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{{STRUCTURE_1wu3|  PDB=1wu3  |  SCENE=  }}  
{{STRUCTURE_1wu3|  PDB=1wu3  |  SCENE=  }}  


'''Crystal structure of recombinant murine interferon beta'''
===Crystal structure of recombinant murine interferon beta===




==Overview==
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The crystal structure of recombinant murine interferon-beta (reMuIFN-beta) has been refined at 2.15 A resolution using newly collected synchrotron data. Based on 11,228 reflections (8.0 to 2.15 A), a final R-factor of 19.1% (with a free R-factor of 25.8%) was obtained with a model obeying standard geometry within 0.013 A in bond lengths and 1.4 degrees in bond angles. Compared with the previously reported model, several amino acid residues in helix A are frame-shifted, the conformations are changed for parts of loops AB and BC, helix C is extended and a new short helix exists in loop CD. Evolutionary considerations taken together, the type I interferons appear to share common structural features with respect to the chain-folding topology and the hydrogen-bond networks between various polypeptide segments. Specifically, the disposition of the C-terminal segment of loop AB (after Arg33), known to be an important receptor-binding site, seems to be strictly maintained among the type I interferons. The exposed amino acid residues on helices A and C, which have recently been implicated as the binding site for another receptor molecule, are less well conserved. This may be responsible for varied cellular effects among the subtypes of type I interferons.
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{{ABSTRACT_PUBMED_7473712}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Refined crystal structure of recombinant murine interferon-beta at 2.15 A resolution., Senda T, Saitoh S, Mitsui Y, J Mol Biol. 1995 Oct 13;253(1):187-207. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7473712 7473712]
Refined crystal structure of recombinant murine interferon-beta at 2.15 A resolution., Senda T, Saitoh S, Mitsui Y, J Mol Biol. 1995 Oct 13;253(1):187-207. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7473712 7473712]
Three-dimensional crystal structure of recombinant murine interferon-beta., Senda T, Shimazu T, Matsuda S, Kawano G, Shimizu H, Nakamura KT, Mitsui Y, EMBO J. 1992 Sep;11(9):3193-201. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1505514 1505514]
Structural, functional and evolutionary implications of the three-dimensional crystal structure of murine interferon-beta., Mitsui Y, Senda T, Shimazu T, Matsuda S, Utsumi J, Pharmacol Ther. 1993;58(1):93-132. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8415875 8415875]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Senda, T.]]
[[Category: Senda, T.]]
[[Category: Alpha-helix-bundle]]
[[Category: Alpha-helix-bundle]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:08:15 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:23:53 2008''
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