2i5x: Difference between revisions

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[[Image:2i5x.~~gif~~|left|200px]]

[[Image:2i5x.png|left|200px]]

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~~'''~~Engineering the PTPbeta catalytic domain with improved crystallization properties~~'''~~

===Engineering the PTPbeta catalytic domain with improved crystallization properties===

~~==Overview==~~

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~~Protein tyrosine phosphatases (PTPs) play roles in many biological processes and are considered to be important targets for drug discovery. As inhibitor development has proven challenging~~, ~~crystal structure-based design will be very helpful~~ to ~~advance inhibitor potency and selectivity~~. ~~Successful application of protein crystallography to drug discovery heavily relies on high-quality crystal structures of the protein of interest complexed with pharmaceutically interesting ligands~~. It is ~~very important to be able to produce protein-ligand crystals rapidly and reproducibly for as many ligands as necessary. This study details our efforts to engineer~~ the ~~catalytic domain of human protein tyrosine phosphatase beta (HPTPbeta-CD) with properties suitable for rapid-turnaround crystallography~~. ~~Structures of apo HPTPbeta~~-~~CD and its complexes with several novel small~~-~~molecule inhibitors are presented here for the first time.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17139078}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17139078 is the PubMed ID number.

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==About this Structure==

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[[Category: Protein tyrosine phosphatase]]

[[Category: Wpd-loop]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 07~~:07:00 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:37:15 2008''

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-[[Image:2i5x.gif|left|200px]]
+{{Seed}}
+[[Image:2i5x.png|left|200px]]
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 {{STRUCTURE_2i5x|  PDB=2i5x  |  SCENE=  }}
-'''Engineering the PTPbeta catalytic domain with improved crystallization properties'''
+===Engineering the PTPbeta catalytic domain with improved crystallization properties===
-==Overview==
+<!--
-Protein tyrosine phosphatases (PTPs) play roles in many biological processes and are considered to be important targets for drug discovery. As inhibitor development has proven challenging, crystal structure-based design will be very helpful to advance inhibitor potency and selectivity. Successful application of protein crystallography to drug discovery heavily relies on high-quality crystal structures of the protein of interest complexed with pharmaceutically interesting ligands. It is very important to be able to produce protein-ligand crystals rapidly and reproducibly for as many ligands as necessary. This study details our efforts to engineer the catalytic domain of human protein tyrosine phosphatase beta (HPTPbeta-CD) with properties suitable for rapid-turnaround crystallography. Structures of apo HPTPbeta-CD and its complexes with several novel small-molecule inhibitors are presented here for the first time.
+The line below this paragraph, {{ABSTRACT_PUBMED_17139078}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17139078 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17139078}}
 ==About this Structure==
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 [[Category: Protein tyrosine phosphatase]]
 [[Category: Wpd-loop]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:07:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:37:15 2008''