3bcj: Difference between revisions

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{{Seed}}
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{{STRUCTURE_3bcj|  PDB=3bcj  |  SCENE=  }}  
{{STRUCTURE_3bcj|  PDB=3bcj  |  SCENE=  }}  


'''Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A'''
===Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A===




==Overview==
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The structure of human aldose reductase in complex with the 2 S4 R stereoisomer of the potent inhibitor Fidarestat ((2 S,4 S)-6-fluoro-2',5'-dioxospiro-[chroman-4,4'-imidazoline]-2-carboxamide) was determined at 15 K and a resolution of 0.78 A. The structure of the complex provides experimental evidence for the inhibition mechanism in which Fidarestat is initially bound neutral and then becomes negatively charged by donating the proton at the 1'-position nitrogen of the cyclic imide ring to the N2 atom of the catalytic His110.
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{{ABSTRACT_PUBMED_18284183}}


==About this Structure==
==About this Structure==
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[[Category: Polyl pathway]]
[[Category: Polyl pathway]]
[[Category: Polymorphism]]
[[Category: Polymorphism]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:41:57 2008''
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