1rzb: Difference between revisions

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[[Image:1rzb.~~jpg~~|left|200px]]

[[Image:1rzb.png|left|200px]]

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~~'''~~X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES~~'''~~

===X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES===

~~==Overview==~~

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~~Metal-substituted crystals of human carbonic anhydrase II belonging to space group P2(1) with cell dimensions a = 42.7~~, ~~b = 41.7~~, ~~c = 73.0 A and beta = 104.6 degrees were analyzed crystallographically. The resolution limit ranged from 1.82~~ to ~~1.92 A with high completeness~~ (86.~~2-90.7%)~~. ~~Cobalt(II~~)~~-substituted carbonic anhydrase has a tetrahedral coordination around the metal both at pH 6 and pH 7.8, similar to the native zinc enzyme. In contrast~~, the ~~catalytically inactive copper(II), nickel(II) and manganese(II) derivatives showed increased coordination~~ number ~~around the metal ion~~. ~~Whereas the copper is best described as penta~~-~~coordinated, the nickel and manganese are best described as hexa~~-~~coordinated. The results are briefly compared with spectroscopic observations and our current view on carbonic anhydrase catalysis.~~

The line below this paragraph, {{ABSTRACT_PUBMED_15299481}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15299481 is the PubMed ID number.

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==About this Structure==

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[[Category: Liljas, A.]]

[[Category: Wehnert, A.]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 08~~:05:55 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:45:11 2008''

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-[[Image:1rzb.jpg|left|200px]]
+{{Seed}}
+[[Image:1rzb.png|left|200px]]
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 {{STRUCTURE_1rzb|  PDB=1rzb  |  SCENE=  }}
-'''X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES'''
+===X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES===
-==Overview==
+<!--
-Metal-substituted crystals of human carbonic anhydrase II belonging to space group P2(1) with cell dimensions a = 42.7, b = 41.7, c = 73.0 A and beta = 104.6 degrees were analyzed crystallographically. The resolution limit ranged from 1.82 to 1.92 A with high completeness (86.2-90.7%). Cobalt(II)-substituted carbonic anhydrase has a tetrahedral coordination around the metal both at pH 6 and pH 7.8, similar to the native zinc enzyme. In contrast, the catalytically inactive copper(II), nickel(II) and manganese(II) derivatives showed increased coordination number around the metal ion. Whereas the copper is best described as penta-coordinated, the nickel and manganese are best described as hexa-coordinated. The results are briefly compared with spectroscopic observations and our current view on carbonic anhydrase catalysis.
+The line below this paragraph, {{ABSTRACT_PUBMED_15299481}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15299481 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15299481}}
 ==About this Structure==
@@ Line 26: / Line 30: @@
 [[Category: Liljas, A.]]
 [[Category: Wehnert, A.]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:05:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:45:11 2008''