2i40: Difference between revisions

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[[Image:2i40.gif|left|200px]]
{{Seed}}
[[Image:2i40.png|left|200px]]


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{{STRUCTURE_2i40|  PDB=2i40  |  SCENE=  }}  
{{STRUCTURE_2i40|  PDB=2i40  |  SCENE=  }}  


'''Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor'''
===Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor===




==Overview==
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The identification and hit-to-lead exploration of a novel, potent and selective series of substituted benzimidazole-thiophene carbonitrile inhibitors of IKK-epsilon kinase is described. Compound 12e was identified with an IKK-epsilon enzyme potency of pIC(50) 7.4, and has a highly encouraging wider selectivity profile, including selectivity within the IKK kinase family.
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{{ABSTRACT_PUBMED_16997559}}


==About this Structure==
==About this Structure==
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[[Category: Cyclin]]
[[Category: Cyclin]]
[[Category: Kinase]]
[[Category: Kinase]]
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