3b4c: Difference between revisions

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[[Image:3b4c.gif|left|200px]]
{{Seed}}
[[Image:3b4c.png|left|200px]]


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{{STRUCTURE_3b4c|  PDB=3b4c  |  SCENE=  }}  
{{STRUCTURE_3b4c|  PDB=3b4c  |  SCENE=  }}  


'''T. tengcongensis glmS ribozyme bound to glucosamine-6-phosphate and a substrate RNA with a 2'5'-phosphodiester linkage'''
===T. tengcongensis glmS ribozyme bound to glucosamine-6-phosphate and a substrate RNA with a 2'5'-phosphodiester linkage===




==Overview==
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The glmS ribozyme is a catalytic riboswitch that is activated for endonucleolytic cleavage by the coenzyme glucosamine-6-phosphate. Using kinetic assays and X-ray crystallography, we identify an active-site mutation of a conserved guanine that abolishes catalysis without perturbing coenzyme binding. Our results provide evidence that coenzyme function requires a specific nucleobase to interact with the nucleophile of the cleavage reaction.
The line below this paragraph, {{ABSTRACT_PUBMED_17990888}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17990888 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17990888}}


==About this Structure==
==About this Structure==
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[[Category: Ribozyme]]
[[Category: Ribozyme]]
[[Category: Rna]]
[[Category: Rna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:22:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:11:03 2008''
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