1nbc: Difference between revisions

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[[Image:1nbc.gif|left|200px]]
{{Seed}}
[[Image:1nbc.png|left|200px]]


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{{STRUCTURE_1nbc|  PDB=1nbc  |  SCENE=  }}  
{{STRUCTURE_1nbc|  PDB=1nbc  |  SCENE=  }}  


'''BACTERIAL TYPE 3A CELLULOSE-BINDING DOMAIN'''
===BACTERIAL TYPE 3A CELLULOSE-BINDING DOMAIN===




==Overview==
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The crystal structure of a family-III cellulose-binding domain (CBD) from the cellulosomal scaffoldin subunit of Clostridium thermocellum has been determined at 1.75 A resolution. The protein forms a nine-stranded beta sandwich with a jelly roll topology and binds a calcium ion. conserved, surface-exposed residues map into two defined surfaces located on opposite sides of the molecule. One of these faces is dominated by a planar linear strip of aromatic and polar residues which are proposed to interact with crystalline cellulose. The other conserved residues are contained in a shallow groove, the function of which is currently unknown, and which has not been observed previously in other families of CBDs. On the basis of modeling studies combined with comparisons of recently determined NMR structures for other CBDs, a general model for the binding of CBDs to cellulose is presented. Although the proposed binding of the CBD to cellulose is essentially a surface interaction, specific types and combinations of amino acids appear to interact selectively with glucose moieties positioned on three adjacent chains of the cellulose surface. The major interaction is characterized by the planar strip of aromatic residues, which align along one of the chains. In addition, polar amino acid residues are proposed to anchor the CBD molecule to two other adjacent chains of crystalline cellulose.
The line below this paragraph, {{ABSTRACT_PUBMED_8918451}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_8918451}}


==About this Structure==
==About this Structure==
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[[Category: Cellulosome]]
[[Category: Cellulosome]]
[[Category: Scafoldin]]
[[Category: Scafoldin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:33:04 2008''

Revision as of 22:33, 27 July 2008

File:1nbc.png

Template:STRUCTURE 1nbc

BACTERIAL TYPE 3A CELLULOSE-BINDING DOMAIN

Template:ABSTRACT PUBMED 8918451

About this Structure

1NBC is a Single protein structure of sequence from Clostridium thermocellum. Full crystallographic information is available from OCA.

Reference

Crystal structure of a bacterial family-III cellulose-binding domain: a general mechanism for attachment to cellulose., Tormo J, Lamed R, Chirino AJ, Morag E, Bayer EA, Shoham Y, Steitz TA, EMBO J. 1996 Nov 1;15(21):5739-51. PMID:8918451

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