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| [[Image:2yxf.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2yxf| PDB=2yxf | SCENE= }} | | {{STRUCTURE_2yxf| PDB=2yxf | SCENE= }} |
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| '''The high resolution crystal structure of beta2-microglobulin under physiological conditions'''
| | ===The high resolution crystal structure of beta2-microglobulin under physiological conditions=== |
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| ==Overview==
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| beta(2)-Microglobulin (beta2-m), a light chain of the major histocompatibility complex class I, forms amyloid fibrils in patients undergoing long-term haemodialysis, causing dialysis-related amyloidosis. Based on a comparison of the X-ray structure obtained at pH 5.7 and that of beta2-m in the histocompatibility complex, it has been proposed that the continuous D-strand observed in the crystal structure at pH 5.7 increases the propensity of beta2-m to self-associate via edge-to-edge interactions, thus initiating the formation of fibrils. To obtain further insight into the mechanism by which amyloid fibrils form, we determined the crystal structure of beta2-m at pH 7.0 at a resolution of up to 1.13 A. The crystal structure at pH 7.0 was basically the same as that at pH 5.6, suggesting that the conversion of the beta-bulge in strand D into a contiguous beta-strand is not unique to the crystals formed under slightly acidic conditions. In other words, although the formation of beta2-m fibrils was enhanced under acidic conditions, it remains unknown if it is related to the increased propensity for the disappearance of the beta-bulge in strand D. We consider that the enhanced fibrillation is more directly coupled with the decreased stability leading to the increased propensity of exposing amyloidogenic regions.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17646174}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17646174 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17646174}} |
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| ==Disease== | | ==Disease== |
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| [[Category: Nakagawa, A.]] | | [[Category: Nakagawa, A.]] |
| [[Category: Immune system]] | | [[Category: Immune system]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 19:38:49 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:33:29 2008'' |
