2cn8: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:2cn8.jpg|left|200px]]
{{Seed}}
[[Image:2cn8.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2cn8|  PDB=2cn8  |  SCENE=  }}  
{{STRUCTURE_2cn8|  PDB=2cn8  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH DEBROMOHYMENIALDISINE'''
===CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH DEBROMOHYMENIALDISINE===




==Overview==
<!--
The protein kinase Chk2 (checkpoint kinase 2) is a major effector of the replication checkpoint. Chk2 activation is initiated by phosphorylation of Thr68, in the serine-glutamine/threonine-glutamine cluster domain (SCD), by ATM. The phosphorylated SCD-segment binds to the FHA domain of a second Chk2 molecule, promoting dimerisation of the protein and triggering phosphorylation of the activation segment/T-loop in the kinase domain. We have now determined the structure of the kinase domain of human Chk2 in complexes with ADP and a small-molecule inhibitor debromohymenialdisine. The structure reveals a remarkable dimeric arrangement in which T-loops are exchanged between protomers, to form an active kinase conformation in trans. Biochemical data suggest that this dimer is the biologically active state promoted by ATM-phosphorylation, and also suggests a mechanism for dimerisation-driven activation of Chk2 by trans-phosphorylation.
The line below this paragraph, {{ABSTRACT_PUBMED_16794575}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16794575 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16794575}}


==About this Structure==
==About this Structure==
Line 42: Line 46:
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Tumour suppressor]]
[[Category: Tumour suppressor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 22:34:03 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:57:09 2008''

Revision as of 22:57, 27 July 2008

File:2cn8.png

Template:STRUCTURE 2cn8

CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH DEBROMOHYMENIALDISINE

Template:ABSTRACT PUBMED 16794575

About this Structure

2CN8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange., Oliver AW, Paul A, Boxall KJ, Barrie SE, Aherne GW, Garrett MD, Mittnacht S, Pearl LH, EMBO J. 2006 Jul 12;25(13):3179-90. Epub 2006 Jun 22. PMID:16794575

Page seeded by OCA on Mon Jul 28 01:57:09 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2cn8&oldid=675585"