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| {{STRUCTURE_2of3| PDB=2of3 | SCENE= }} | | {{STRUCTURE_2of3| PDB=2of3 | SCENE= }} |
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| '''TOG domain structure from C.elegans Zyg9'''
| | ===TOG domain structure from C.elegans Zyg9=== |
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| ==Overview==
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| Members of the XMAP215/Dis1 family of microtubule-associated proteins (MAPs) are essential for microtubule growth. MAPs in this family contain several 250 residue repeats, called TOG domains, which are thought to bind tubulin dimers and promote microtubule polymerization. We have determined the crystal structure of a single TOG domain from the Caenorhabditis elegans homolog, Zyg9, to 1.9 A resolution, and from it we describe a structural blueprint for TOG domains. These domains are flat, paddle-like structures, composed of six HEAT-repeat elements stacked side by side. The two wide faces of the paddle contain the HEAT-repeat helices, and the two narrow faces, the intra- and inter-HEAT repeat turns. Solvent-exposed residues in the intrarepeat turns are conserved, both within a particular protein and across the XMAP215/Dis1 family. Mutation of some of these residues in the TOG1 domain from the budding yeast homolog, Stu2p, shows that this face indeed participates in the tubulin contact.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17355870}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17355870 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17355870}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Xmap215]] | | [[Category: Xmap215]] |
| [[Category: Zyg9]] | | [[Category: Zyg9]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:46:22 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:05:19 2008'' |
