1psp: Difference between revisions

Line 1:

[[Image:1psp.~~gif~~|left|200px]]

[[Image:1psp.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~PANCREATIC SPASMOLYTIC POLYPEPTIDE: FIRST THREE-DIMENSIONAL STRUCTURE OF A MEMBER OF THE MAMMALIAN TREFOIL FAMILY OF PEPTIDES~~'''~~

===PANCREATIC SPASMOLYTIC POLYPEPTIDE: FIRST THREE-DIMENSIONAL STRUCTURE OF A MEMBER OF THE MAMMALIAN TREFOIL FAMILY OF PEPTIDES===

~~==Overview==~~

<!--

~~BACKGROUND:~~ The ~~trefoil peptides are a rapidly growing family of peptides~~, ~~mainly found in the gastrointestinal tract. There is circumstantial evidence that they stabilize the mucus layer~~, ~~and may affect~~ the ~~rate of healing of~~ the ~~mucosal epithelium. RESULTS~~: ~~We have determined the structure of porcine pancreatic spasmolytic polypeptide (PSP) to 2~~.~~5 A resolution~~. ~~The polypeptide contains two trefoil domains. The domain structure is compact~~, ~~and~~ is ~~composed of a central short antiparallel beta-sheet with one short helix above and one below it~~. ~~This is a novel motif. The two domains are related by two~~-fold symmetry, and each domain contains a cleft. CONCLUSIONS: The cleft within each domain could accommodate a polysaccharide chain, and may therefore be responsible for binding mucin glycoproteins. We suggest that PSP may cross-~~link glycoproteins, explaining its ability to stabilize the mucus layer.~~

The line below this paragraph, {{ABSTRACT_PUBMED_8081739}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8081739 is the PubMed ID number.

-->

==About this Structure==

Line 30:

Line 34:

[[Category: Wilson, K S.]]

[[Category: Spasmolytic protein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 05~~:26:37 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:35:30 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1psp.gif|left|200px]]
+{{Seed}}
+[[Image:1psp.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1psp|  PDB=1psp  |  SCENE=  }}
-'''PANCREATIC SPASMOLYTIC POLYPEPTIDE: FIRST THREE-DIMENSIONAL STRUCTURE OF A MEMBER OF THE MAMMALIAN TREFOIL FAMILY OF PEPTIDES'''
+===PANCREATIC SPASMOLYTIC POLYPEPTIDE: FIRST THREE-DIMENSIONAL STRUCTURE OF A MEMBER OF THE MAMMALIAN TREFOIL FAMILY OF PEPTIDES===
-==Overview==
+<!--
-BACKGROUND: The trefoil peptides are a rapidly growing family of peptides, mainly found in the gastrointestinal tract. There is circumstantial evidence that they stabilize the mucus layer, and may affect the rate of healing of the mucosal epithelium. RESULTS: We have determined the structure of porcine pancreatic spasmolytic polypeptide (PSP) to 2.5 A resolution. The polypeptide contains two trefoil domains. The domain structure is compact, and is composed of a central short antiparallel beta-sheet with one short helix above and one below it. This is a novel motif. The two domains are related by two-fold symmetry, and each domain contains a cleft. CONCLUSIONS: The cleft within each domain could accommodate a polysaccharide chain, and may therefore be responsible for binding mucin glycoproteins. We suggest that PSP may cross-link glycoproteins, explaining its ability to stabilize the mucus layer.
+The line below this paragraph, {{ABSTRACT_PUBMED_8081739}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8081739 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8081739}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Wilson, K S.]]
 [[Category: Spasmolytic protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:26:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:35:30 2008''