1q68: Difference between revisions

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[[Image:1q68.gif|left|200px]]
{{Seed}}
[[Image:1q68.png|left|200px]]


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{{STRUCTURE_1q68|  PDB=1q68  |  SCENE=  }}  
{{STRUCTURE_1q68|  PDB=1q68  |  SCENE=  }}  


'''Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments'''
===Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments===




==Overview==
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The T cell coreceptors CD4 and CD8 both associate via their cytoplasmic tails with the N-terminus of the Src-family tyrosine kinase Lck. These interactions require zinc and are critical for T cell development and activation. We examined the folding and solution structures of ternary CD4-Lck-Zn2+ and CD8alpha-Lck-Zn2+ complexes. The coreceptor tails and the Lck N-terminus are unstructured in isolation but assemble in the presence of zinc to form compactly folded heterodimeric domains. The cofolded complexes have similar "zinc clasp" cores that are augmented by distinct structural elements. A dileucine motif required for clathrin-mediated endocytosis of CD4 is masked by Lck.
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{{ABSTRACT_PUBMED_14500983}}


==Disease==
==Disease==
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]
Known disease associated with this structure: CD4  lymphocyte deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]], Lupus erythematosus, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]], SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]


==About this Structure==
==About this Structure==
1Q68 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q68 OCA].  
1Q68 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q68 OCA].  


==Reference==
==Reference==
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[[Category: Peptide-peptide complex]]
[[Category: Peptide-peptide complex]]
[[Category: Zinc coordination]]
[[Category: Zinc coordination]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:54:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:35:54 2008''

Revision as of 23:35, 27 July 2008

File:1q68.png

Template:STRUCTURE 1q68

Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments

Template:ABSTRACT PUBMED 14500983

Disease

Known disease associated with this structure: CD4 lymphocyte deficiency OMIM:[186940], Lupus erythematosus, susceptibility to OMIM:[186940], SCID due to LCK deficiency OMIM:[153390]

About this Structure

1Q68 is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8., Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ, Science. 2003 Sep 19;301(5640):1725-8. PMID:14500983

Page seeded by OCA on Mon Jul 28 02:35:54 2008

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