1t7k: Difference between revisions

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[[Image:1t7k.gif|left|200px]]
{{Seed}}
[[Image:1t7k.png|left|200px]]


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{{STRUCTURE_1t7k|  PDB=1t7k  |  SCENE=  }}  
{{STRUCTURE_1t7k|  PDB=1t7k  |  SCENE=  }}  


'''Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea'''
===Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea===




==Overview==
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A series of novel azacyclic urea HIV protease inhibitors bearing a benzenesulfonamide group at P1' were synthesized utilizing a parallel synthesis method. Structural studies of early analogs bound in the enzyme active site were used to design more potent inhibitors. The effects of substituting the P1' benzenesulfonyl group on antiviral activity and protein binding are described.
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{{ABSTRACT_PUBMED_15225729}}


==About this Structure==
==About this Structure==
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[[Category: Arylsulfonamide azacyclic urea]]
[[Category: Arylsulfonamide azacyclic urea]]
[[Category: Hiv protease]]
[[Category: Hiv protease]]
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