2hxq: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
Line 1: Line 1:
[[Image:2hxq.jpg|left|200px]]
{{Seed}}
[[Image:2hxq.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2hxq|  PDB=2hxq  |  SCENE=  }}  
{{STRUCTURE_2hxq|  PDB=2hxq  |  SCENE=  }}  


'''crystal structure of Chek1 in complex with inhibitor 2'''
===crystal structure of Chek1 in complex with inhibitor 2===




==Overview==
<!--  
Through a comparison of X-ray co-crystallographic data for 1 and 2 in the Chek1 active site, it was hypothesized that the affinity of the indolylquinolinone series (2) for Chek1 kinase would be improved via C6 substitution into the hydrophobic region I (HI) pocket. An efficient route to 6-bromo-3-indolyl-quinolinone (9) was developed, and this series was rapidly optimized for potency by modification at C6. A general trend was observed among these low nanomolar Chek1 inhibitors that compounds with multiple basic amines, or elevated polar surface area (PSA) exhibited poor cell potency. Minimization of these parameters (basic amines, PSA) resulted in Chek1 inhibitors with improved cell potency, and preliminary pharmacokinetic data are presented for several of these compounds.
The line below this paragraph, {{ABSTRACT_PUBMED_16990002}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16990002 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16990002}}


==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Chek1]]
[[Category: Chek1]]
[[Category: Kinase]]
[[Category: Kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:50:19 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:44:47 2008''
Retrieved from "https://proteopedia.org/2hxq"