359d: Difference between revisions

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[[Image:359d.jpg|left|200px]]
{{Seed}}
[[Image:359d.png|left|200px]]


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{{STRUCTURE_359d|  PDB=359d  |  SCENE=  }}  
{{STRUCTURE_359d|  PDB=359d  |  SCENE=  }}  


'''INHIBITION OF THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION BY SITE-SPECIFIC BINDING OF TB(III)'''
===INHIBITION OF THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION BY SITE-SPECIFIC BINDING OF TB(III)===




==Overview==
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Terbium(III) [Tb(III)] was shown to inhibit the hammerhead ribozyme by competing with a single magnesium(II) ion. X-ray crystallography revealed that the Tb(III) ion binds to a site adjacent to an essential guanosine in the catalytic core of the ribozyme, approximately 10 angstroms from the cleavage site. Synthetic modifications near this binding site yielded an RNA substrate that was resistant to Tb(III) binding and capable of being cleaved, even in the presence of up to 20 micromolar Tb(III). It is suggested that the magnesium(II) ion thought to bind at this site may act as a switch, affecting the conformational changes required to achieve the transition state.
The line below this paragraph, {{ABSTRACT_PUBMED_9417029}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9417029 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9417029}}


==About this Structure==
==About this Structure==
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[[Category: Loop]]
[[Category: Loop]]
[[Category: Rna hammerhead ribozyme]]
[[Category: Rna hammerhead ribozyme]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:17:09 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:24:29 2008''

Revision as of 00:24, 28 July 2008

File:359d.png

Template:STRUCTURE 359d

INHIBITION OF THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION BY SITE-SPECIFIC BINDING OF TB(III)

Template:ABSTRACT PUBMED 9417029

About this Structure

Full crystallographic information is available from OCA.

Reference

Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb., Feig AL, Scott WG, Uhlenbeck OC, Science. 1998 Jan 2;279(5347):81-4. PMID:9417029

Page seeded by OCA on Mon Jul 28 03:24:29 2008

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