1qse: Difference between revisions

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[[Image:1qse.~~gif~~|left|200px]]

[[Image:1qse.png|left|200px]]

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~~'''~~STRUCTURE OF HUMAN A6-TCR BOUND TO HLA-A2 COMPLEXED WITH ALTERED HTLV-1 TAX PEPTIDE V7R~~'''~~

===STRUCTURE OF HUMAN A6-TCR BOUND TO HLA-A2 COMPLEXED WITH ALTERED HTLV-1 TAX PEPTIDE V7R===

~~==Overview==~~

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The ~~interactions of three singly substituted peptide variants of~~ the ~~HTLV-1 Tax peptide bound~~ to ~~HLA-A2 with~~ the ~~A6 T cell receptor have been studied using T cell assays, kinetic and thermodynamic measurements, and X-ray crystallography~~. ~~The three peptide/MHC ligands include weak agonists and antagonists with different affinities for TCR~~. ~~The three-dimensional structures of the three A6-TCR/peptide/HLA-A2 complexes are remarkably similar to each other and to the wild-type agonist complex~~, ~~with minor adjustments at~~ the ~~interface to accommodate the peptide substitutions (P6A, V7R, and Y8A)~~. ~~The lack of correlation between structural changes and the type of T cell signals induced provides direct evidence that different signals are not generated by different ligand~~-~~induced conformational changes in the alphabeta TCR.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10435578}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10435578 is the PubMed ID number.

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==About this Structure==

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[[Category: Human t cell receptor]]

[[Category: Tcr/peptide/mhc complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 06~~:39:04 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:32:02 2008''

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-[[Image:1qse.gif|left|200px]]
+{{Seed}}
+[[Image:1qse.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1qse|  PDB=1qse  |  SCENE=  }}
-'''STRUCTURE OF HUMAN A6-TCR BOUND TO HLA-A2 COMPLEXED WITH ALTERED HTLV-1 TAX PEPTIDE V7R'''
+===STRUCTURE OF HUMAN A6-TCR BOUND TO HLA-A2 COMPLEXED WITH ALTERED HTLV-1 TAX PEPTIDE V7R===
-==Overview==
+<!--
-The interactions of three singly substituted peptide variants of the HTLV-1 Tax peptide bound to HLA-A2 with the A6 T cell receptor have been studied using T cell assays, kinetic and thermodynamic measurements, and X-ray crystallography. The three peptide/MHC ligands include weak agonists and antagonists with different affinities for TCR. The three-dimensional structures of the three A6-TCR/peptide/HLA-A2 complexes are remarkably similar to each other and to the wild-type agonist complex, with minor adjustments at the interface to accommodate the peptide substitutions (P6A, V7R, and Y8A). The lack of correlation between structural changes and the type of T cell signals induced provides direct evidence that different signals are not generated by different ligand-induced conformational changes in the alphabeta TCR.
+The line below this paragraph, {{ABSTRACT_PUBMED_10435578}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10435578 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10435578}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Human t cell receptor]]
 [[Category: Tcr/peptide/mhc complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:39:04 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:32:02 2008''