2cs7: Difference between revisions

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[[Image:2cs7.~~gif~~|left|200px]]

[[Image:2cs7.png|left|200px]]

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~~'''~~1.2 A Crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold~~'''~~

===1.2 A Crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold===

~~==Overview==~~

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The recently described pneumococcal histidine triad protein family has been shown to be highly conserved within the pneumococcus. As part of our structural genomics effort on proteins from Streptococcus pneumoniae, ~~we have expressed~~, ~~crystallised and solved~~ the ~~structure of PhtA-166-220 at 1.2 Angstroms using remote SAD with zinc. The structure of PhtA-166-220 shows no similarity~~ to ~~any protein structure. The overall fold contains 3beta-strands and a single short alpha-helix. The structure~~ appears ~~to contain a novel zinc binding motif~~. ~~The remaining 4 histidine triad repeats from PhtA have been modelled based on the crystal structure of the PhtA histidine triad repeat 2~~. ~~From this modelling work~~, ~~we speculate that only three of~~ the ~~five histidine triad repeats contain the residues in the correct geometry to allow the binding of a zinc ion~~.

The line below this paragraph, {{ABSTRACT_PUBMED_16194532}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16194532 is the PubMed ID number.

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==About this Structure==

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[[Category: Pneumococcal histidine triad protein]]

[[Category: S pneumoniae]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 22~~:55:55 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:41:42 2008''

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-[[Image:2cs7.gif|left|200px]]
+{{Seed}}
+[[Image:2cs7.png|left|200px]]
 <!--
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 {{STRUCTURE_2cs7|  PDB=2cs7  |  SCENE=  }}
-'''1.2 A Crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold'''
+===1.2 A Crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold===
-==Overview==
+<!--
-The recently described pneumococcal histidine triad protein family has been shown to be highly conserved within the pneumococcus. As part of our structural genomics effort on proteins from Streptococcus pneumoniae, we have expressed, crystallised and solved the structure of PhtA-166-220 at 1.2 Angstroms using remote SAD with zinc. The structure of PhtA-166-220 shows no similarity to any protein structure. The overall fold contains 3beta-strands and a single short alpha-helix. The structure appears to contain a novel zinc binding motif. The remaining 4 histidine triad repeats from PhtA have been modelled based on the crystal structure of the PhtA histidine triad repeat 2. From this modelling work, we speculate that only three of the five histidine triad repeats contain the residues in the correct geometry to allow the binding of a zinc ion.
+The line below this paragraph, {{ABSTRACT_PUBMED_16194532}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16194532 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16194532}}
 ==About this Structure==
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 [[Category: Pneumococcal histidine triad protein]]
 [[Category: S pneumoniae]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 22:55:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:41:42 2008''