2d1o: Difference between revisions

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[[Image:2d1o.gif|left|200px]]
{{Seed}}
[[Image:2d1o.png|left|200px]]


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{{STRUCTURE_2d1o|  PDB=2d1o  |  SCENE=  }}  
{{STRUCTURE_2d1o|  PDB=2d1o  |  SCENE=  }}  


'''Stromelysin-1 (MMP-3) complexed to a hydroxamic acid inhibitor'''
===Stromelysin-1 (MMP-3) complexed to a hydroxamic acid inhibitor===




==Overview==
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Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453 have been solved at 2.01 and 2.37A resolutions, respectively. The results revealed that the binding modes for this inhibitor to MMP-3 and -13 were quite similar. However, subtle comparative differences were observed at the bottom of S1' pockets, which were occupied with the guanidinomethyl moiety of the inhibitor. A remarkable feature of the inhibitor was the deep penetration of its long aliphatic chain into the S1' pocket and exposure of the guanidinomethyl moiety to the solvent.
The line below this paragraph, {{ABSTRACT_PUBMED_16603129}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16603129 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16603129}}


==About this Structure==
==About this Structure==
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[[Category: Yamashita, E.]]
[[Category: Yamashita, E.]]
[[Category: Hydorolase metalloprotease]]
[[Category: Hydorolase metalloprotease]]
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