1pzw: Difference between revisions

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[[Image:1pzw.gif|left|200px]]
{{Seed}}
[[Image:1pzw.png|left|200px]]


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{{STRUCTURE_1pzw|  PDB=1pzw  |  SCENE=  }}  
{{STRUCTURE_1pzw|  PDB=1pzw  |  SCENE=  }}  


'''Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone'''
===Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone===




==Overview==
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About one-third of the more than 300 C2H2 zinc finger proteins of Drosophila contain a conserved sequence motif, the zinc finger-associated domain (ZAD). Genes that encode ZAD proteins are specific for and expanded in the genomes of insects. Only three ZAD-encoding gene functions are established, and the role of ZAD is unknown. Here we present the crystal structure of the ZAD of Grauzone (ZAD(Grau)), a Drosophila transcription factor that specifically controls the maternal Cdc20-like APC subunit Cortex. ZAD forms an atypical treble-clef-like zinc-coordinating fold. Head-to-tail arrangement of two ZAD(Grau) molecules in the crystals suggests dimer formation, an observation supported by crosslinking and dynamic light scattering. The results indicate that ZAD provides a novel protein-protein interaction module that characterizes a large family of insect transcription factors.
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{{ABSTRACT_PUBMED_14604529}}


==About this Structure==
==About this Structure==
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[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
[[Category: Zad]]
[[Category: Zad]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:41:44 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:57:36 2008''

Revision as of 00:57, 28 July 2008

File:1pzw.png

Template:STRUCTURE 1pzw

Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone

Template:ABSTRACT PUBMED 14604529

About this Structure

1PZW is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

The zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module., Jauch R, Bourenkov GP, Chung HR, Urlaub H, Reidt U, Jackle H, Wahl MC, Structure. 2003 Nov;11(11):1393-402. PMID:14604529

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