1y97: Difference between revisions

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[[Image:1y97.gif|left|200px]]
{{Seed}}
[[Image:1y97.png|left|200px]]


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{{STRUCTURE_1y97|  PDB=1y97  |  SCENE=  }}  
{{STRUCTURE_1y97|  PDB=1y97  |  SCENE=  }}  


'''The human TREX2 3' exonuclease structure suggests a mechanism for efficient non-processive DNA catalysis'''
===The human TREX2 3' exonuclease structure suggests a mechanism for efficient non-processive DNA catalysis===




==Overview==
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The 3' --&gt; 5'-exonucleases process DNA ends in many DNA repair pathways of human cells. Determination of the human TREX2 structure is the first of a dimeric 3'-deoxyribonuclease and indicates how this highly efficient nonprocessive enzyme removes nucleotides at DNA 3' termini. Symmetry in the TREX2 dimer positions the active sites at opposite outer edges providing open access for the DNA. Adjacent to each active site is a flexible region containing three arginines positioned appropriately to bind DNA and to control its entry into the active site. Mutation of these three arginines to alanines reduces the DNA binding capacity by approximately 100-fold with no effect on catalysis. The human TREX2 catalytic residues overlay with the bacterial DnaQ family of 3'-exonucleases confirming the structural conservation of the catalytic sites despite limited sequence identity, and mutations of these residues decrease the still measurable activity by approximately 10(5)-fold, confirming their catalytic role.
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{{ABSTRACT_PUBMED_15661738}}


==About this Structure==
==About this Structure==
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[[Category: Exonuclease]]
[[Category: Exonuclease]]
[[Category: Trex2]]
[[Category: Trex2]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:01:58 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:07:53 2008''

Revision as of 01:07, 28 July 2008

File:1y97.png

Template:STRUCTURE 1y97

The human TREX2 3' exonuclease structure suggests a mechanism for efficient non-processive DNA catalysis

Template:ABSTRACT PUBMED 15661738

About this Structure

1Y97 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis., Perrino FW, Harvey S, McMillin S, Hollis T, J Biol Chem. 2005 Apr 15;280(15):15212-8. Epub 2005 Jan 19. PMID:15661738

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