1x93: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 1: Line 1:
[[Image:1x93.gif|left|200px]]
{{Seed}}
[[Image:1x93.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1x93|  PDB=1x93  |  SCENE=  }}  
{{STRUCTURE_1x93|  PDB=1x93  |  SCENE=  }}  


'''NMR Structure of Helicobacter pylori HP0222'''
===NMR Structure of Helicobacter pylori HP0222===




==Overview==
<!--
Helicobacter pylori is a widespread human bacterial pathogen responsible for inducing gastric and duodenal ulcers and gastric cancers. To date, only 16 protein structures from this organism have been determined, and more than 30% of its 1500 protein functions remain unknown. We report the biochemical characterization, the tertiary structure determined by solution nuclear magnetic resonance (NMR) methods and the putative function of the previously uncharacterized protein HP0222 (JHP0208) from H. pylori. Recombinant HP0222 behaves as a dimer in crosslinking and size exclusion chromatography experiments. The structure consists of a ribbon-helix-helix fold characteristic of transcription factors of the Arc/MetJ family, which all bind DNA as higher order oligomers. Electrophoretic mobility shift assays reveal that HP0222 binds to double-stranded DNA. Previous studies have shown significant increases in transcription levels of HP0222 in response to acid shock and adherence to gastric epithelial cells. To assess possible involvement of HP0222 in acid resistance, we constructed and assayed an H. pylori HP0222 null mutant. We propose that HP0222 is a novel transcriptional regulator in H. pylori.
The line below this paragraph, {{ABSTRACT_PUBMED_15723352}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15723352 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_15723352}}


==About this Structure==
==About this Structure==
1X93 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X93 OCA].  
1X93 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X93 OCA].  


==Reference==
==Reference==
Line 39: Line 43:
[[Category: Repa]]
[[Category: Repa]]
[[Category: Transcription]]
[[Category: Transcription]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:43:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:10:53 2008''

Revision as of 01:10, 28 July 2008

File:1x93.png

Template:STRUCTURE 1x93

NMR Structure of Helicobacter pylori HP0222

Template:ABSTRACT PUBMED 15723352

About this Structure

1X93 is a Single protein structure of sequence from Helicobacter pylori 26695. Full experimental information is available from OCA.

Reference

Helicobacter pylori protein HP0222 belongs to Arc/MetJ family of transcriptional regulators., Popescu A, Karpay A, Israel DA, Peek RM Jr, Krezel AM, Proteins. 2005 May 1;59(2):303-11. PMID:15723352

Page seeded by OCA on Mon Jul 28 04:10:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1x93&oldid=680464"