2p59: Difference between revisions

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[[Image:2p59.jpg|left|200px]]
{{Seed}}
[[Image:2p59.png|left|200px]]


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{{STRUCTURE_2p59|  PDB=2p59  |  SCENE=  }}  
{{STRUCTURE_2p59|  PDB=2p59  |  SCENE=  }}  


'''Crystal Structure of Hepatitis C Virus NS3.4A protease'''
===Crystal Structure of Hepatitis C Virus NS3.4A protease===




==Overview==
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Reversible tetrapeptide-based compounds have been shown to effectively inhibit the hepatitis C virus NS3.4A protease. Inhibition of viral replicon RNA production in Huh-7 cells has also been demonstrated. We show herein that the inclusion of hydrogen bond donors on the P4 capping group of tetrapeptide-based inhibitors result in increased binding potency to the NS3.4A protease. The capping groups also impart significant effects on the pharmacokinetic profile of these inhibitors.
The line below this paragraph, {{ABSTRACT_PUBMED_17482818}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17482818 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17482818}}


==About this Structure==
==About this Structure==
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[[Category: Hcv protease]]
[[Category: Hcv protease]]
[[Category: Viral protein]]
[[Category: Viral protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 12:23:32 2008''
 
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