1y6n: Difference between revisions

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[[Image:1y6n.png|left|200px]]

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~~'''~~Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain~~'''~~

===Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain===

~~==Overview==~~

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~~Human IL~~-~~10 (hIL~~-~~10) is a cytokine that modulates diverse immune responses.~~ The ~~Epstein-Barr virus (EBV) genome contains an IL-10 homolog (vIL-10) that shares high sequence and structural similarity with hIL-10. Although vIL-10 suppresses inflammatory responses like hIL-10~~, it cannot activate many other immunostimulatory functions performed by the cellular cytokine. These functional differences have been correlated with the approximately 1000-fold lower affinity of vIL-10, compared to hIL-10, ~~for the IL-10R1 receptor chain. To define~~ the ~~structural basis for these observations, crystal structures of vIL-10 and a vIL-10 point mutant were determined bound~~ to the ~~soluble IL-10R1 receptor fragment~~ (~~sIL-10R1)~~ at 2.~~8 and 2~~.~~7 A resolution~~, ~~respectively~~. ~~The structures reveal that subtle changes in the conformation and dynamics of the vIL~~-~~10 AB and CD loops and an orientation change of vIL~~-~~10 on sIL-10R1 are the main factors responsible for vIL-10's reduced affinity for sIL-10R1 and its distinct biological profile.~~

The line below this paragraph, {{ABSTRACT_PUBMED_15837194}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15837194 is the PubMed ID number.

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==About this Structure==

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[[Category: Helix bundle]]

[[Category: Receptor complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 15~~:56:14 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:11:43 2008''

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-[[Image:1y6n.gif|left|200px]]
+{{Seed}}
+[[Image:1y6n.png|left|200px]]
 <!--
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 {{STRUCTURE_1y6n|  PDB=1y6n  |  SCENE=  }}
-'''Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain'''
+===Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain===
-==Overview==
+<!--
-Human IL-10 (hIL-10) is a cytokine that modulates diverse immune responses. The Epstein-Barr virus (EBV) genome contains an IL-10 homolog (vIL-10) that shares high sequence and structural similarity with hIL-10. Although vIL-10 suppresses inflammatory responses like hIL-10, it cannot activate many other immunostimulatory functions performed by the cellular cytokine. These functional differences have been correlated with the approximately 1000-fold lower affinity of vIL-10, compared to hIL-10, for the IL-10R1 receptor chain. To define the structural basis for these observations, crystal structures of vIL-10 and a vIL-10 point mutant were determined bound to the soluble IL-10R1 receptor fragment (sIL-10R1) at 2.8 and 2.7 A resolution, respectively. The structures reveal that subtle changes in the conformation and dynamics of the vIL-10 AB and CD loops and an orientation change of vIL-10 on sIL-10R1 are the main factors responsible for vIL-10's reduced affinity for sIL-10R1 and its distinct biological profile.
+The line below this paragraph, {{ABSTRACT_PUBMED_15837194}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15837194 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15837194}}
 ==About this Structure==
@@ Line 29: / Line 33: @@
 [[Category: Helix bundle]]
 [[Category: Receptor complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:56:14 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:11:43 2008''