2fa3: Difference between revisions

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[[Image:2fa3.gif|left|200px]]
{{Seed}}
[[Image:2fa3.png|left|200px]]


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{{STRUCTURE_2fa3|  PDB=2fa3  |  SCENE=  }}  
{{STRUCTURE_2fa3|  PDB=2fa3  |  SCENE=  }}  


'''HMG-CoA synthase from Brassica juncea in complex with acetyl-CoA and acetyl-cys117.'''
===HMG-CoA synthase from Brassica juncea in complex with acetyl-CoA and acetyl-cys117.===




==Overview==
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3-Hydroxy-3-methylglutaryl CoA synthase (HMGS) catalyzes the first committed step in the mevalonate metabolic pathway for isoprenoid biosynthesis and serves as an alternative target for cholesterol-lowering and antibiotic drugs. We have determined a previously undescribed crystal structure of a eukaryotic HMGS bound covalently to a potent and specific inhibitor F-244 [(E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecad ienenoic acid]. Given the accessibility of synthetic analogs of the F-244 natural product, this inhibited eukaryotic HMGS structure serves as a necessary starting point for structure-based methods that may improve the potency and species-specific selectivity of the next generation of F-244 analogs designed to target particular eukaryotic and prokaryotic HMGS.
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{{ABSTRACT_PUBMED_16864776}}


==About this Structure==
==About this Structure==
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[[Category: Acetyl-coa]]
[[Category: Acetyl-coa]]
[[Category: Hmgs1]]
[[Category: Hmgs1]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:39:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:24:54 2008''

Revision as of 01:25, 28 July 2008

File:2fa3.png

Template:STRUCTURE 2fa3

HMG-CoA synthase from Brassica juncea in complex with acetyl-CoA and acetyl-cys117.

Template:ABSTRACT PUBMED 16864776

About this Structure

2FA3 is a Single protein structure of sequence from Brassica juncea. Full crystallographic information is available from OCA.

Reference

Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases., Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel JP, Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11491-6. Epub 2006 Jul 24. PMID:16864776

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