2cme: Difference between revisions

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[[Image:2cme.gif|left|200px]]
{{Seed}}
[[Image:2cme.png|left|200px]]


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{{STRUCTURE_2cme|  PDB=2cme  |  SCENE=  }}  
{{STRUCTURE_2cme|  PDB=2cme  |  SCENE=  }}  


'''THE CRYSTAL STRUCTURE OF SARS CORONAVIRUS ORF-9B PROTEIN'''
===THE CRYSTAL STRUCTURE OF SARS CORONAVIRUS ORF-9B PROTEIN===




==Overview==
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To achieve the greatest output from their limited genomes, viruses frequently make use of alternative open reading frames, in which translation is initiated from a start codon within an existing gene and, being out of frame, gives rise to a distinct protein product. These alternative protein products are, as yet, poorly characterized structurally. Here we report the crystal structure of ORF-9b, an alternative open reading frame within the nucleocapsid (N) gene from the SARS coronavirus. The protein has a novel fold, a dimeric tent-like beta structure with an amphipathic surface, and a central hydrophobic cavity that binds lipid molecules. This cavity is likely to be involved in membrane attachment and, in mammalian cells, ORF-9b associates with intracellular vesicles, consistent with a role in the assembly of the virion. Analysis of ORF-9b and other overlapping genes suggests that they provide snapshots of the early evolution of novel protein folds.
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{{ABSTRACT_PUBMED_16843897}}


==About this Structure==
==About this Structure==
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[[Category: Lipid-binding]]
[[Category: Lipid-binding]]
[[Category: Virus assembly]]
[[Category: Virus assembly]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 22:30:25 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:31:57 2008''

Revision as of 01:31, 28 July 2008

File:2cme.png

Template:STRUCTURE 2cme

THE CRYSTAL STRUCTURE OF SARS CORONAVIRUS ORF-9B PROTEIN

Template:ABSTRACT PUBMED 16843897

About this Structure

2CME is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.

Reference

The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus., Meier C, Aricescu AR, Assenberg R, Aplin RT, Gilbert RJ, Grimes JM, Stuart DI, Structure. 2006 Jul;14(7):1157-65. PMID:16843897

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