1z1c: Difference between revisions

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[[Image:1z1c.gif|left|200px]]
{{Seed}}
[[Image:1z1c.png|left|200px]]


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{{STRUCTURE_1z1c|  PDB=1z1c  |  SCENE=  }}  
{{STRUCTURE_1z1c|  PDB=1z1c  |  SCENE=  }}  


'''Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute virus of Mice'''
===Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute virus of Mice===




==Overview==
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Two strains of the parvovirus minute virus of mice (MVM), the immunosuppressive (MVMi) and the prototype (MVMp) strains, display disparate in vitro tropism and in vivo pathogenicity. We report the crystal structures of MVMp virus-like particles (MVMp(b)) and native wild-type (wt) empty capsids (MVMp(e)), determined and refined to 3.25 and 3.75 A resolution, respectively, and their comparison to the structure of MVMi, also refined to 3.5 A resolution in this study. A comparison of the MVMp(b) and MVMp(e) capsids showed their structures to be the same, providing structural verification that some heterologously expressed parvovirus capsids are indistinguishable from wt capsids produced in host cells. The structures of MVMi and MVMp capsids were almost identical, but local surface conformational differences clustered from symmetry-related capsid proteins at three specific domains: (i) the icosahedral fivefold axis, (ii) the "shoulder" of the protrusion at the icosahedral threefold axis, and (iii) the area surrounding the depression at the icosahedral twofold axis. The latter two domains contain important determinants of MVM in vitro tropism (residues 317 and 321) and forward mutation residues (residues 399, 460, 553, and 558) conferring fibrotropism on MVMi. Furthermore, these structural differences between the MVM strains colocalize with tropism and pathogenicity determinants mapped for other autonomous parvovirus capsids, highlighting the importance of common parvovirus capsid regions in the control of virus-host interactions.
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{{ABSTRACT_PUBMED_16103145}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice., Kontou M, Govindasamy L, Nam HJ, Bryant N, Llamas-Saiz AL, Foces-Foces C, Hernando E, Rubio MP, McKenna R, Almendral JM, Agbandje-McKenna M, J Virol. 2005 Sep;79(17):10931-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16103145 16103145]
Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice., Kontou M, Govindasamy L, Nam HJ, Bryant N, Llamas-Saiz AL, Foces-Foces C, Hernando E, Rubio MP, McKenna R, Almendral JM, Agbandje-McKenna M, J Virol. 2005 Sep;79(17):10931-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16103145 16103145]
Structure determination of minute virus of mice., Llamas-Saiz AL, Agbandje-McKenna M, Wikoff WR, Bratton J, Tattersall P, Rossmann MG, Acta Crystallogr D Biol Crystallogr. 1997 Jan 1;53(Pt 1):93-102. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15299974 15299974]
[[Category: Minute virus of mice]]
[[Category: Minute virus of mice]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Minute virus of mice]]
[[Category: Minute virus of mice]]
[[Category: Mvmi]]
[[Category: Mvmi]]
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