1sr6: Difference between revisions

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[[Image:1sr6.gif|left|200px]]
{{Seed}}
[[Image:1sr6.png|left|200px]]


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{{STRUCTURE_1sr6|  PDB=1sr6  |  SCENE=  }}  
{{STRUCTURE_1sr6|  PDB=1sr6  |  SCENE=  }}  


'''Structure of nucleotide-free scallop myosin S1'''
===Structure of nucleotide-free scallop myosin S1===




==Overview==
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Structural studies of myosin have indicated some of the conformational changes that occur in this protein during the contractile cycle, and we have now observed a conformational change in a bound nucleotide as well. The 3.1-A x-ray structure of the scallop myosin head domain (subfragment 1) in the ADP-bound near-rigor state (lever arm =45 degrees to the helical actin axis) shows the diphosphate moiety positioned on the surface of the nucleotide-binding pocket, rather than deep within it as had been observed previously. This conformation strongly suggests a specific mode of entry and exit of the nucleotide from the nucleotide-binding pocket through the so-called "front door." In addition, using a variety of scallop structures, including a relatively high-resolution 2.75-A nucleotide-free near-rigor structure, we have identified a conserved complex salt bridge connecting the 50-kDa upper and N-terminal subdomains. This salt bridge is present only in crystal structures of muscle myosin isoforms that exhibit a strong reciprocal relationship (also known as coupling) between actin and nucleotide affinity.
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{{ABSTRACT_PUBMED_15184651}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Myosin subfragment 1 structures reveal a partially bound nucleotide and a complex salt bridge that helps couple nucleotide and actin binding., Risal D, Gourinath S, Himmel DM, Szent-Gyorgyi AG, Cohen C, Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8930-5. Epub 2004 Jun 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15184651 15184651]
Myosin subfragment 1 structures reveal a partially bound nucleotide and a complex salt bridge that helps couple nucleotide and actin binding., Risal D, Gourinath S, Himmel DM, Szent-Gyorgyi AG, Cohen C, Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8930-5. Epub 2004 Jun 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15184651 15184651]
Crystal structure of scallop Myosin s1 in the pre-power stroke state to 2.6 a resolution: flexibility and function in the head., Gourinath S, Himmel DM, Brown JH, Reshetnikova L, Szent-Gyorgyi AG, Cohen C, Structure. 2003 Dec;11(12):1621-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14656445 14656445]
Crystallographic findings on the internally uncoupled and near-rigor states of myosin: further insights into the mechanics of the motor., Himmel DM, Gourinath S, Reshetnikova L, Shen Y, Szent-Gyorgyi AG, Cohen C, Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12645-50. Epub 2002 Sep 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12297624 12297624]
[[Category: Argopecten irradians]]
[[Category: Argopecten irradians]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Novel conformation of nucleotide]]
[[Category: Novel conformation of nucleotide]]
[[Category: Scallop myosin s1]]
[[Category: Scallop myosin s1]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:03:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:35:45 2008''

Revision as of 01:35, 28 July 2008

File:1sr6.png

Template:STRUCTURE 1sr6

Structure of nucleotide-free scallop myosin S1

Template:ABSTRACT PUBMED 15184651

About this Structure

1SR6 is a Protein complex structure of sequences from Argopecten irradians. Full crystallographic information is available from OCA.

Reference

Myosin subfragment 1 structures reveal a partially bound nucleotide and a complex salt bridge that helps couple nucleotide and actin binding., Risal D, Gourinath S, Himmel DM, Szent-Gyorgyi AG, Cohen C, Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8930-5. Epub 2004 Jun 7. PMID:15184651

Crystal structure of scallop Myosin s1 in the pre-power stroke state to 2.6 a resolution: flexibility and function in the head., Gourinath S, Himmel DM, Brown JH, Reshetnikova L, Szent-Gyorgyi AG, Cohen C, Structure. 2003 Dec;11(12):1621-7. PMID:14656445

Crystallographic findings on the internally uncoupled and near-rigor states of myosin: further insights into the mechanics of the motor., Himmel DM, Gourinath S, Reshetnikova L, Shen Y, Szent-Gyorgyi AG, Cohen C, Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12645-50. Epub 2002 Sep 24. PMID:12297624

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