2g6w: Difference between revisions

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[[Image:2g6w.~~gif~~|left|200px]]

[[Image:2g6w.png|left|200px]]

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~~'''~~Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine~~'''~~

===Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine===

~~==Overview==~~

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The ~~irreversible inhibition of 8-amino-7-oxononanoate synthase by trifluoroalanine involves decarboxylative defluorination of~~ the ~~inhibitor-PLP aldimine followed by attack of~~ the ~~conjugated imine by the amino group of the active site lysine to afford a covalently bound difluorinated intermediate which can subsequently undergo further HF losses and hydrolysis to afford a 2-~~(~~pyridoximine phosphate~~) ~~acetoyl protein adduct~~.

The line below this paragraph, {{ABSTRACT_PUBMED_16557306}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16557306 is the PubMed ID number.

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==About this Structure==

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[[Category: Plp]]

[[Category: Synthase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4~~ 04:45:27 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:42:54 2008''

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-[[Image:2g6w.gif|left|200px]]
+{{Seed}}
+[[Image:2g6w.png|left|200px]]
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 {{STRUCTURE_2g6w|  PDB=2g6w  |  SCENE=  }}
-'''Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine'''
+===Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine===
-==Overview==
+<!--
-The irreversible inhibition of 8-amino-7-oxononanoate synthase by trifluoroalanine involves decarboxylative defluorination of the inhibitor-PLP aldimine followed by attack of the conjugated imine by the amino group of the active site lysine to afford a covalently bound difluorinated intermediate which can subsequently undergo further HF losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl protein adduct.
+The line below this paragraph, {{ABSTRACT_PUBMED_16557306}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16557306 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16557306}}
 ==About this Structure==
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 [[Category: Plp]]
 [[Category: Synthase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:45:27 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:42:54 2008''