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| {{STRUCTURE_1rrp| PDB=1rrp | SCENE= }} | | {{STRUCTURE_1rrp| PDB=1rrp | SCENE= }} |
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| '''STRUCTURE OF THE RAN-GPPNHP-RANBD1 COMPLEX'''
| | ===STRUCTURE OF THE RAN-GPPNHP-RANBD1 COMPLEX=== |
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| ==Overview==
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| The protein Ran is a small GTP-binding protein that binds to two types of effector inside the cell: Ran-binding proteins, which have a role in terminating export processes from the nucleus to the cytoplasm, and importin-beta-like molecules that bind cargo proteins during nuclear transport. The Ran-binding domain is a conserved sequence motif found in several proteins that participate in these transport processes. The Ran-binding protein RanBP2 contains four of these domains and constitutes a large part of the cytoplasmic fibrils that extend from the nuclear-pore complex. The structure of Ran bound to a non-hydrolysable GTP analogue (Ran x GppNHp) in complex with the first Ran-binding domain (RanBD1) of human RanBP2 reveals not only that RanBD1 has a pleckstrin-homology domain fold, but also that the switch-I region of Ran x GppNHp resembles the canonical Ras GppNHp structure and that the carboxy terminus of Ran is wrapped around RanBD1, contacting a basic patch on RanBD1 through its acidic end. This molecular 'embrace' enables RanBDs to sequester the Ran carboxy terminus, triggering the dissociation of Ran x GTP from importin-beta-related transport factors and facilitating GTP hydrolysis by the GTPase-activating protein ranGAP. Such a mechanism represents a new type of switch mechanism and regulatory protein-protein interaction for a Ras-related protein. | | The line below this paragraph, {{ABSTRACT_PUBMED_10078529}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 10078529 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_10078529}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Nuclear transport]] | | [[Category: Nuclear transport]] |
| [[Category: Small gtpase]] | | [[Category: Small gtpase]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:50:01 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:49:57 2008'' |
