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| {{STRUCTURE_2j6k| PDB=2j6k | SCENE= }} | | {{STRUCTURE_2j6k| PDB=2j6k | SCENE= }} |
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| '''N-TERMINAL SH3 DOMAIN OF CMS (CD2AP HUMAN HOMOLOG)'''
| | ===N-TERMINAL SH3 DOMAIN OF CMS (CD2AP HUMAN HOMOLOG)=== |
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| ==Overview==
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| The CIN85/CMS (human homologs of mouse SH3KBP1/CD2AP) family of endocytic adaptor proteins has the ability to engage multiple effectors and couple cargo trafficking with the cytoskeleton. CIN85 and CMS (Cas ligand with multiple Src homology 3 (SH3) domains) facilitate the formation of large multiprotein complexes required for an efficient internalization of cell surface receptors. It has recently been shown that c-Cbl/Cbl-b could mediate the formation of a ternary complex between one c-Cbl/Cbl-b molecule and two SH3 domains of CIN85, important for the ability of Cbl to promote epidermal growth factor receptor down-regulation. To further investigate whether multimerization is conserved within the family of adaptor proteins, we have solved the crystal structures of the CMS N-terminal SH3 domain-forming complexes with Cbl-b- and CD2-derived peptides. Together with biochemical evidence, the structures support the notion that, despite clear differences in the interaction surface, both Cbl-b and CD2 can mediate multimerization of N-terminal CMS SH3 domains. Detailed analyses on the interacting surfaces also provide the basis for a differential Cbl-b molecular recognition of CMS and CIN85. | | The line below this paragraph, {{ABSTRACT_PUBMED_17020880}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17020880 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17020880}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Signaling protein]] | | [[Category: Signaling protein]] |
| [[Category: Surface active protein]] | | [[Category: Surface active protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:25:10 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:52:36 2008'' |
