2opy: Difference between revisions

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[[Image:2opy.gif|left|200px]]
{{Seed}}
[[Image:2opy.png|left|200px]]


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{{STRUCTURE_2opy|  PDB=2opy  |  SCENE=  }}  
{{STRUCTURE_2opy|  PDB=2opy  |  SCENE=  }}  


'''Smac mimic bound to BIR3-XIAP'''
===Smac mimic bound to BIR3-XIAP===




==Overview==
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A small series of peptide mimics was designed and synthesized to contain a heterocyclic ring in place of the potentially labile N-terminal peptide bond of the tetrapeptide containing the Smac-XIAP-binding motif. Two Smac mimics were shown to bind to the BIR3 domain of XIAP with moderate affinity and one displayed increased activity in cells relative to the Smac peptides. The structures of BIR3-XIAP in complex with a Smac peptide and a peptide mimic were solved and analyzed to elucidate the structure-activity relationship surrounding the Smac-binding domain within BIR3-XIAP.
The line below this paragraph, {{ABSTRACT_PUBMED_17336535}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17336535 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17336535}}


==About this Structure==
==About this Structure==
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[[Category: Bir3]]
[[Category: Bir3]]
[[Category: Peptide mimic]]
[[Category: Peptide mimic]]
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