1ngw: Difference between revisions

Line 1:

[[Image:1ngw.~~gif~~|left|200px]]

[[Image:1ngw.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Chimeric Affinity Matured Fab 7g12 complexed with mesoporphyrin~~'''~~

===Chimeric Affinity Matured Fab 7g12 complexed with mesoporphyrin===

~~==Overview==~~

<!--

The ~~crystal structure of~~ the ~~Michaelis complex between~~ the ~~Fab fragment of ferrochelatase antibody 7G12 and its substrate mesoporphyrin has been solved to 2~~.~~6-A resolution~~. ~~The antibody-bound mesoporphyrin clearly adopts a nonplanar conformation and reveals that the antibody catalyzes the porphyrin metallation reaction by straining/distorting the bound substrate toward~~ the ~~transition-state configuration~~. ~~The crystal structures of the Fab fragment of the germ~~-~~line precursor antibody to 7G12 and its complex with the hapten N~~-methylmesoporphyrin have also been solved. A comparison of these structures with the corresponding structures of the affinity-matured antibody 7G12 reveals the molecular mechanism by which the immune system evolves binding energy to catalyze this reaction.

The line below this paragraph, {{ABSTRACT_PUBMED_12552112}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12552112 is the PubMed ID number.

-->

==About this Structure==

Line 30:

Line 34:

[[Category: Antigen binding fragment]]

[[Category: Immunoglobulin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 02~~:30:57 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:56:06 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1ngw.gif|left|200px]]
+{{Seed}}
+[[Image:1ngw.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1ngw|  PDB=1ngw  |  SCENE=  }}
-'''Chimeric Affinity Matured Fab 7g12 complexed with mesoporphyrin'''
+===Chimeric Affinity Matured Fab 7g12 complexed with mesoporphyrin===
-==Overview==
+<!--
-The crystal structure of the Michaelis complex between the Fab fragment of ferrochelatase antibody 7G12 and its substrate mesoporphyrin has been solved to 2.6-A resolution. The antibody-bound mesoporphyrin clearly adopts a nonplanar conformation and reveals that the antibody catalyzes the porphyrin metallation reaction by straining/distorting the bound substrate toward the transition-state configuration. The crystal structures of the Fab fragment of the germ-line precursor antibody to 7G12 and its complex with the hapten N-methylmesoporphyrin have also been solved. A comparison of these structures with the corresponding structures of the affinity-matured antibody 7G12 reveals the molecular mechanism by which the immune system evolves binding energy to catalyze this reaction.
+The line below this paragraph, {{ABSTRACT_PUBMED_12552112}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12552112 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12552112}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Antigen binding fragment]]
 [[Category: Immunoglobulin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:30:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:56:06 2008''