2r18: Difference between revisions

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[[Image:2r18.~~jpg~~|left|200px]]

[[Image:2r18.png|left|200px]]

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~~'''~~Structural insights into the multifunctional protein VP3 of Birnaviruses~~'''~~

===Structural insights into the multifunctional protein VP3 of Birnaviruses===

~~==Overview==~~

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~~Infectious bursal disease virus (IBDV)~~, ~~a member of the Birnaviridae family~~, is the ~~causative agent of one of~~ the ~~most harmful poultry diseases~~. ~~The IBDV genome encodes five mature proteins; of these, the multifunctional protein VP3 plays an essential role in virus morphogenesis~~. ~~This protein, which interacts with the structural protein VP2, with the double-stranded RNA genome, and with the virus-encoded, RNA-dependent RNA polymerase, VP1~~, is ~~involved not only in the formation of the viral capsid, but also in~~ the ~~recruitment of VP1 into the capsid and in the encapsidation of the viral genome~~. ~~Here, we report the X~~-~~ray structure of the central region of VP3, residues 92~~-220, consisting of two alpha-helical domains connected by a long and flexible hinge that are organized as a dimer. Unexpectedly, the overall fold of the second VP3 domain shows significant structural similarities with different transcription regulation factors.

The line below this paragraph, {{ABSTRACT_PUBMED_18184581}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18184581 is the PubMed ID number.

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==About this Structure==

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[[Category: Viral protein]]

[[Category: Virion]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 16~~:04:13 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:01:13 2008''

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-[[Image:2r18.jpg|left|200px]]
+{{Seed}}
+[[Image:2r18.png|left|200px]]
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 {{STRUCTURE_2r18|  PDB=2r18  |  SCENE=  }}
-'''Structural insights into the multifunctional protein VP3 of Birnaviruses'''
+===Structural insights into the multifunctional protein VP3 of Birnaviruses===
-==Overview==
+<!--
-Infectious bursal disease virus (IBDV), a member of the Birnaviridae family, is the causative agent of one of the most harmful poultry diseases. The IBDV genome encodes five mature proteins; of these, the multifunctional protein VP3 plays an essential role in virus morphogenesis. This protein, which interacts with the structural protein VP2, with the double-stranded RNA genome, and with the virus-encoded, RNA-dependent RNA polymerase, VP1, is involved not only in the formation of the viral capsid, but also in the recruitment of VP1 into the capsid and in the encapsidation of the viral genome. Here, we report the X-ray structure of the central region of VP3, residues 92-220, consisting of two alpha-helical domains connected by a long and flexible hinge that are organized as a dimer. Unexpectedly, the overall fold of the second VP3 domain shows significant structural similarities with different transcription regulation factors.
+The line below this paragraph, {{ABSTRACT_PUBMED_18184581}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18184581 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18184581}}
 ==About this Structure==
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 [[Category: Viral protein]]
 [[Category: Virion]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 16:04:13 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:01:13 2008''