2rll: Difference between revisions

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[[Image:2rll.jpg|left|200px]]
{{Seed}}
[[Image:2rll.png|left|200px]]


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{{STRUCTURE_2rll|  PDB=2rll  |  SCENE=  }}  
{{STRUCTURE_2rll|  PDB=2rll  |  SCENE=  }}  


'''CCR5 Nt(7-15)'''
===CCR5 Nt(7-15)===




==Overview==
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The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and facilitates HIV-1 entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on gp120. We applied nuclear magnetic resonance and crystallographic techniques to analyze the structure of the CCR5 N terminus and that of the tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The conformations of tyrosine-sulfated regions of CCR5 (alpha-helix) and 412d (extended loop) are surprisingly different. Nonetheless, a critical sulfotyrosine on CCR5 and on 412d induces similar structural rearrangements in gp120. These results now provide a framework for understanding HIV-1 interactions with the CCR5 N terminus during viral entry and define a conserved site on gp120, whose recognition of sulfotyrosine engenders posttranslational mimicry by the immune system.
The line below this paragraph, {{ABSTRACT_PUBMED_17901336}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17901336 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17901336}}


==About this Structure==
==About this Structure==
2RLL is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLL OCA].  
2RLL is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLL OCA].  


==Reference==
==Reference==
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[[Category: Transducer]]
[[Category: Transducer]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:08:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:02:20 2008''
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