1y5i: Difference between revisions

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[[Image:1y5i.gif|left|200px]]
{{Seed}}
[[Image:1y5i.png|left|200px]]


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{{STRUCTURE_1y5i|  PDB=1y5i  |  SCENE=  }}  
{{STRUCTURE_1y5i|  PDB=1y5i  |  SCENE=  }}  


'''The crystal structure of the NarGHI mutant NarI-K86A'''
===The crystal structure of the NarGHI mutant NarI-K86A===




==Overview==
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The crystal structure of Escherichia coli nitrate reductase A (NarGHI) in complex with pentachlorophenol has been determined to 2.0 A of resolution. We have shown that pentachlorophenol is a potent inhibitor of quinol:nitrate oxidoreductase activity and that it also perturbs the EPR spectrum of one of the hemes located in the membrane anchoring subunit (NarI). This new structural information together with site-directed mutagenesis data, biochemical analyses, and molecular modeling provide the first molecular characterization of a quinol binding and oxidation site (Q-site) in NarGHI. A possible proton conduction pathway linked to electron transfer reactions has also been defined, providing fundamental atomic details of ubiquinol oxidation by NarGHI at the bacterial membrane.
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{{ABSTRACT_PUBMED_15615728}}


==About this Structure==
==About this Structure==
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[[Category: Nitrate reduction]]
[[Category: Nitrate reduction]]
[[Category: Q-site]]
[[Category: Q-site]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:54:03 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:10:23 2008''

Revision as of 03:10, 28 July 2008

File:1y5i.png

Template:STRUCTURE 1y5i

The crystal structure of the NarGHI mutant NarI-K86A

Template:ABSTRACT PUBMED 15615728

About this Structure

1Y5I is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A., Bertero MG, Rothery RA, Boroumand N, Palak M, Blasco F, Ginet N, Weiner JH, Strynadka NC, J Biol Chem. 2005 Apr 15;280(15):14836-43. Epub 2004 Dec 22. PMID:15615728

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