2bub: Difference between revisions

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[[Image:2bub.gif|left|200px]]
{{Seed}}
[[Image:2bub.png|left|200px]]


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{{STRUCTURE_2bub|  PDB=2bub  |  SCENE=  }}  
{{STRUCTURE_2bub|  PDB=2bub  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV (CD26) IN COMPLEX WITH A REVERSED AMIDE INHIBITOR'''
===CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV (CD26) IN COMPLEX WITH A REVERSED AMIDE INHIBITOR===




==Overview==
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The co-crystal structure of beta-phenethylamine fragment inhibitor 5 bound to DPP-IV revealed that the phenyl ring occupied the proline pocket of the enzyme. This finding provided the basis for a general hypothesis of a reverse binding mode for beta-phenethylamine-based DPP-IV inhibitors. Novel inhibitor design concepts that obviate substrate-like structure-activity relationships (SAR) were thereby enabled, and novel, potent inhibitors were discovered.
The line below this paragraph, {{ABSTRACT_PUBMED_16376544}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16376544 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16376544}}


==About this Structure==
==About this Structure==
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[[Category: Signal-anchor]]
[[Category: Signal-anchor]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:48:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:11:42 2008''
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