3bwu: Difference between revisions

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[[Image:3bwu.jpg|left|200px]]
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[[Image:3bwu.png|left|200px]]


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{{STRUCTURE_3bwu|  PDB=3bwu  |  SCENE=  }}  
{{STRUCTURE_3bwu|  PDB=3bwu  |  SCENE=  }}  


'''Crystal structure of the ternary complex of FimD (N-Terminal Domain, FimDN) with FimC and the N-terminally truncated pilus subunit FimF (FimFt)'''
===Crystal structure of the ternary complex of FimD (N-Terminal Domain, FimDN) with FimC and the N-terminally truncated pilus subunit FimF (FimFt)===




==Overview==
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Type 1 pili, anchored to the outer membrane protein FimD, enable uropathogenic Escherichia coli to attach to host cells. During pilus biogenesis, the N-terminal periplasmic domain of FimD (FimD(N)) binds complexes between the chaperone FimC and pilus subunits via its partly disordered N-terminal segment, as recently shown for the FimC-FimH(P)-FimD(N) ternary complex. We report the structure of a new ternary complex (FimC-FimF(t)-FimD(N)) with the subunit FimF(t) instead of FimH(p). FimD(N) recognizes FimC-FimF(t) and FimC-FimH(P) very similarly, predominantly through hydrophobic interactions. The conserved binding mode at a "hot spot" on the chaperone surface could guide the design of pilus assembly inhibitors.
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{{ABSTRACT_PUBMED_18242189}}


==About this Structure==
==About this Structure==
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[[Category: Ternary complex with chaperone and pilus subunit]]
[[Category: Ternary complex with chaperone and pilus subunit]]
[[Category: Usher]]
[[Category: Usher]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 21:10:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:29:10 2008''

Revision as of 03:29, 28 July 2008

File:3bwu.png

Template:STRUCTURE 3bwu

Crystal structure of the ternary complex of FimD (N-Terminal Domain, FimDN) with FimC and the N-terminally truncated pilus subunit FimF (FimFt)

Template:ABSTRACT PUBMED 18242189

About this Structure

3BWU is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the ternary FimC-FimF(t)-FimD(N) complex indicates conserved pilus chaperone-subunit complex recognition by the usher FimD., Eidam O, Dworkowski FS, Glockshuber R, Grutter MG, Capitani G, FEBS Lett. 2008 Mar 5;582(5):651-5. Epub 2008 Jan 31. PMID:18242189

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