2hwi: Difference between revisions

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[[Image:2hwi.gif|left|200px]]
{{Seed}}
[[Image:2hwi.png|left|200px]]


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{{STRUCTURE_2hwi|  PDB=2hwi  |  SCENE=  }}  
{{STRUCTURE_2hwi|  PDB=2hwi  |  SCENE=  }}  


'''HCV NS5B allosteric inhibitor complex'''
===HCV NS5B allosteric inhibitor complex===




==Overview==
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A structure-based approach was performed to design a novel thiazolone scaffold as HCV NS5B inhibitors. A focused library was designed and docked by GOLD. One of the top-scored molecules was synthesized and shown to have similar potency to the initial hit. The X-ray complex structure was determined and validated our design rationale.
The line below this paragraph, {{ABSTRACT_PUBMED_16934455}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16934455 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16934455}}


==About this Structure==
==About this Structure==
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[[Category: Rdrp]]
[[Category: Rdrp]]
[[Category: Viral rna-directed rna polymerase]]
[[Category: Viral rna-directed rna polymerase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:47:54 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:34:04 2008''