1sl7: Difference between revisions

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[[Image:1sl7.~~jpg~~|left|200px]]

[[Image:1sl7.png|left|200px]]

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~~'''~~Crystal structure of calcium-loaded apo-obelin from Obelia longissima~~'''~~

===Crystal structure of calcium-loaded apo-obelin from Obelia longissima===

~~==Overview==~~

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The ~~crystal structures of calcium-loaded apo-aequorin and apo-obelin have been determined at resolutions 1.7A and 2.2 A~~, ~~respectively. A calcium ion is observed in each of the three EF-hand loops that have the canonical calcium-binding sequence~~, ~~and each is coordinated in~~ the ~~characteristic pentagonal bipyramidal configuration. The calcium-loaded apo-protein retain~~ the ~~same compact scaffold and overall fold~~ as ~~the unreacted photoproteins containing the bound substrate, 2-hyroperoxycoelenterazine, and also the same as the Ca2+-discharged obelin bound with product, coleneteramide~~. ~~Nevertheless, there are easily discerned shifts in both helix and loop regions~~, ~~and the shifts are not the same between the two proteins. It~~ is ~~suggested that these photoproteins to sense Ca2+ concentration transients and to produce their bioluminescence response on~~ the ~~millisecond timescale. A mechanism of intrastructural transmission of the calcium signal is proposed~~.

The line below this paragraph, {{ABSTRACT_PUBMED_15689515}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15689515 is the PubMed ID number.

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==About this Structure==

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[[Category: Southeast collaboratory for structural genomic]]

[[Category: Structural genomic]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 08~~:50:33 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:34:52 2008''

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-[[Image:1sl7.jpg|left|200px]]
+{{Seed}}
+[[Image:1sl7.png|left|200px]]
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 {{STRUCTURE_1sl7|  PDB=1sl7  |  SCENE=  }}
-'''Crystal structure of calcium-loaded apo-obelin from Obelia longissima'''
+===Crystal structure of calcium-loaded apo-obelin from Obelia longissima===
-==Overview==
+<!--
-The crystal structures of calcium-loaded apo-aequorin and apo-obelin have been determined at resolutions 1.7A and 2.2 A, respectively. A calcium ion is observed in each of the three EF-hand loops that have the canonical calcium-binding sequence, and each is coordinated in the characteristic pentagonal bipyramidal configuration. The calcium-loaded apo-protein retain the same compact scaffold and overall fold as the unreacted photoproteins containing the bound substrate, 2-hyroperoxycoelenterazine, and also the same as the Ca2+-discharged obelin bound with product, coleneteramide. Nevertheless, there are easily discerned shifts in both helix and loop regions, and the shifts are not the same between the two proteins. It is suggested that these photoproteins to sense Ca2+ concentration transients and to produce their bioluminescence response on the millisecond timescale. A mechanism of intrastructural transmission of the calcium signal is proposed.
+The line below this paragraph, {{ABSTRACT_PUBMED_15689515}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15689515 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15689515}}
 ==About this Structure==
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 [[Category: Southeast collaboratory for structural genomic]]
 [[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:50:33 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:34:52 2008''