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| [[Image:1tl2.jpg|left|200px]] | | {{Seed}} |
| | [[Image:1tl2.png|left|200px]] |
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| {{STRUCTURE_1tl2| PDB=1tl2 | SCENE= }} | | {{STRUCTURE_1tl2| PDB=1tl2 | SCENE= }} |
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| '''TACHYLECTIN-2 FROM TACHYPLEUS TRIDENTATUS (JAPANESE HORSESHOE CRAB)'''
| | ===TACHYLECTIN-2 FROM TACHYPLEUS TRIDENTATUS (JAPANESE HORSESHOE CRAB)=== |
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| ==Overview==
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| Tachylectin-2, isolated from large granules of the hemocytes of the Japanese horseshoe crab (Tachypleus tridentatus), is a 236 amino acid protein belonging to the lectins. It binds specifically to N-acetylglucosamine and N-acetylgalactosamine and is a part of the innate immunity host defense system of the horseshoe crab. The X-ray structure of tachylectin-2 was solved at 2.0 A resolution by the multiple isomorphous replacement method and this molecular model was employed to solve the X-ray structure of the complex with N-acetylglucosamine. Tachylectin-2 is the first protein displaying a five-bladed beta-propeller structure. Five four-stranded antiparallel beta-sheets of W-like topology are arranged around a central water-filled tunnel, with the water molecules arranged as a pentagonal dodecahedron. Tachylectin-2 exhibits five virtually identical binding sites, one in each beta-sheet. The binding sites are located between adjacent beta-sheets and are made by a large loop between the outermost strands of the beta-sheets and the connecting segment from the previous beta-sheet. The high number of five binding sites within the single polypeptide chain strongly suggests the recognition of carbohydrate surface structures of pathogens with a fairly high ligand density. Thus, tachylectin-2 employs strict specificity for certain N-acetyl sugars as well as the surface ligand density for self/non-self recognition.
| | The line below this paragraph, {{ABSTRACT_PUBMED_10228146}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 10228146 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_10228146}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Horseshoe crab]] | | [[Category: Horseshoe crab]] |
| [[Category: N-acetylglucosamine]] | | [[Category: N-acetylglucosamine]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:04:55 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:38:09 2008'' |
